Butyrate-Producing Bacteria as Microbiomarkers of Chronic Kidney Disease Progression in Children.
Gehad, M., Elsaadany, H., El-Korashi, L., Ahmed, A., Yousif, Y. (2023). Butyrate-Producing Bacteria as Microbiomarkers of Chronic Kidney Disease Progression in Children.. EKB Journal Management System, 18(1), 1-11. doi: 10.21608/geget.2023.308020
Mona Hamed Gehad; Hosam Fathi Elsaadany; Lobna El-Korashi; Ali Magdy Ahmed; Yousif Mohamed Yousif. "Butyrate-Producing Bacteria as Microbiomarkers of Chronic Kidney Disease Progression in Children.". EKB Journal Management System, 18, 1, 2023, 1-11. doi: 10.21608/geget.2023.308020
Gehad, M., Elsaadany, H., El-Korashi, L., Ahmed, A., Yousif, Y. (2023). 'Butyrate-Producing Bacteria as Microbiomarkers of Chronic Kidney Disease Progression in Children.', EKB Journal Management System, 18(1), pp. 1-11. doi: 10.21608/geget.2023.308020
Gehad, M., Elsaadany, H., El-Korashi, L., Ahmed, A., Yousif, Y. Butyrate-Producing Bacteria as Microbiomarkers of Chronic Kidney Disease Progression in Children.. EKB Journal Management System, 2023; 18(1): 1-11. doi: 10.21608/geget.2023.308020

Butyrate-Producing Bacteria as Microbiomarkers of Chronic Kidney Disease Progression in Children.

GEGET
Article 1, Volume 18, Issue 1, June 2023, Page 1-11  XML PDF (427.4 K)
Document Type: Original Article
DOI: 10.21608/geget.2023.308020
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Authors
Mona Hamed Gehad email orcid 1; Hosam Fathi Elsaadany1; Lobna El-Korashi2; Ali Magdy Ahmed3; Yousif Mohamed Yousif1
1Department of Pediatrics, Faculty of Medicine, Zagazig University, Sharkia, Egypt
2Department of Microbiology and Immunology, Faculty of Medicine, Zagazig University, Sharkia, Egypt.
3Resident of Pediatrics, Ministry of Health Hospitals, Egypt.
Abstract
Introduction: The gut microbiota is increasingly recognized as a critical component in the control of host health. Dysbiosis and chronic kidney disease (CKD) have a bidirectional link. Butyrate- producing bacteria have recently gained attention and is a poorly understood faecal state in CKD children.
 Aim: to study the variations in butyrate generating species (Roseburia spp. and F. prausnitzii) in the faeces of children with CKD at different stages.
 Methods: A case-control study with 52 CKD children and 26 healthy subjects was conducted. To verify the alterations in these species, the quantitative real-time polymerase chain reaction (qPCR) was performed.
 Results: Roseburia spp. and F. prausnitzii were considerably lower in CKD children compared to controls and were significantly lower in CKD stage5 (p <0.001). The best cutoff of F. prausnitzii ratio for association with end stage renal disease is ≤15.205 with area under curve 0.928 with (p<0.001).  Roseburia spp., F. prausnitzii ratio were statistically significantly lower in CKD patients with thrombosis than cases without evidence of thrombosis (p=0.011, p=0.009) respectively.
Conclusion: The depletion of Roseburia spp. and F. prausnitzii can be considered microbiomarkers of CKD inflammation, thrombosis, and progression in CKD children.
 
Keywords
Butyrate; Roseburia spp; Faecalibacterium prausnitzii; microbiota; chronic kidney disease
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