Ameliorative effects of frankincense oil on rats treated with a minimum toxic dose of paracetamol
Talaat, A., Elgendy, Y., Mohamed, H., Saed, N., Abd Elrouf, N., Elgendy, H., Elbalakousy, H., El hantoshy, N., Elmezaien, M., Sayed, Y., El . Hekal, Y., Gabr, M., Badr, 1. (2023). Ameliorative effects of frankincense oil on rats treated with a minimum toxic dose of paracetamol. EKB Journal Management System, 5(3), 155-175. doi: 10.21608/jmals.2023.308224
Aml Talaat; Yomna A. Elgendy; Heba F. Mohamed; Nouran M Saed; Noran A. Abd Elrouf; Hend A. Elgendy; Hagar H. Elbalakousy; Nourhan N. El hantoshy; Mohammed S. Elmezaien; Youssef M. Sayed; Yosry El . Hekal; Mohamed A. Gabr; 1. Nada S. Badr. "Ameliorative effects of frankincense oil on rats treated with a minimum toxic dose of paracetamol". EKB Journal Management System, 5, 3, 2023, 155-175. doi: 10.21608/jmals.2023.308224
Talaat, A., Elgendy, Y., Mohamed, H., Saed, N., Abd Elrouf, N., Elgendy, H., Elbalakousy, H., El hantoshy, N., Elmezaien, M., Sayed, Y., El . Hekal, Y., Gabr, M., Badr, 1. (2023). 'Ameliorative effects of frankincense oil on rats treated with a minimum toxic dose of paracetamol', EKB Journal Management System, 5(3), pp. 155-175. doi: 10.21608/jmals.2023.308224
Talaat, A., Elgendy, Y., Mohamed, H., Saed, N., Abd Elrouf, N., Elgendy, H., Elbalakousy, H., El hantoshy, N., Elmezaien, M., Sayed, Y., El . Hekal, Y., Gabr, M., Badr, 1. Ameliorative effects of frankincense oil on rats treated with a minimum toxic dose of paracetamol. EKB Journal Management System, 2023; 5(3): 155-175. doi: 10.21608/jmals.2023.308224

Ameliorative effects of frankincense oil on rats treated with a minimum toxic dose of paracetamol

Journal of Medical and Life Science
Volume 5, Issue 3, September 2023, Page 155-175  XML PDF (2.82 MB)
Document Type: Original Article
DOI: 10.21608/jmals.2023.308224
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Authors
Aml Talaat; Yomna A. Elgendy; Heba F. Mohamed; Nouran M Saed; Noran A. Abd Elrouf; Hend A. Elgendy; Hagar H. Elbalakousy; Nourhan N. El hantoshy; Mohammed S. Elmezaien; Youssef M. Sayed; Yosry El . Hekal; Mohamed A. Gabr; 1. Nada S. Badr email
Zoology Department, Faculty of Science, Damanhur University, Egypt
Abstract
Paracetamol is a widely used analgesic and antipyretic drug, but its long-term usage has been associated with potential toxicity. The goal of this study was to investigate how frankincense oil prevents paracetamol toxicity. The study included twenty male albino rats divided into four groups: (G1) control, (G2) paracetamol, (G3) frankincense oil, and (G4) paracetamol + frankincense oil. For three days, 1000 mg/kg paracetamol was given orally, while frankincense oil was given orally at a dosage of 1000 mg/kg concurrently with paracetamol. Hematological parameters, lipid profile, cardiac markers, pancreatic function, blood antioxidant capacity, myeloperoxidase activity, blood, spleen, pancreas, heart, and lung histopathology were evaluated.
Paracetamol caused oxidative stress, hematotoxicity, dyslipidemia, myocardial damage, pancreatic dysfunction, spleen alterations, and lung tissue damage. However, coadministration of paracetamol and frankincense oil protected against these effects by boosting antioxidant capacity, improving hematological parameters, preserving pancreatic function, enhancing lipid profiles, preserving spleen morphology, and preventing lung damage, likely due to the antioxidant properties of frankincense oil.
In conclusion, this study highlights the potential of frankincense oil as a counteractive agent for paracetamol-induced organ toxicity. The findings suggest that frankincense oil supplementation may mitigate the adverse effects of paracetamol, offering a potential therapeutic approach to enhance overall health outcomes.
Keywords
Paracetamol; Toxicity; frankincense oil
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