Relation between Osteoprotegerin Serum Level and Carotid Atherosclerosis | ||||
| Suez Canal University Medical Journal | ||||
| Article 9, Volume 26, Issue 6, June 2023, Page 0-0 | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/scumj.2023.309035 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Dina Mounir   ; Mohamed I. Negm; Mohamed A. Saad; Ahmed O. Hosny; Reda A. Ahmed
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| Department of Neuropsychiatry, Faculty of Medicine, Suez Canal University, Egypt | ||||
| Abstract | ||||
| Background: Osteoprotegerin (OPG) is a member of the TNF receptor superfamily. Substantial studies indicate that OPG abnormality is associated with cardiovascular and cerebrovascular disease Objective: to find out the relationship between Osteoprotegerin (OPG) plasma level and the occurrence of carotid atherosclerosis in ischemic stroke patients. Subjects and Methods: A case-control study was conducted on 50 patients and 50 controls, aged 49-64 years old, patients are diagnosed with ischemic stroke, and recruited from the neuropsychiatry department of Suez Canal university hospital. The plasma OPG serum level was measured by ELISA technique and the status of carotid arteries was studied by high-resolution B-mode ultrasonography. Results: we found a weak positive not statically significant linear correlation between Osteoprotegerin (OPG) serum level and carotid intima-media thickness (r=0.178, p=0.215). Plasma OPG concentrations were none significantly higher in unstable plaques. Conclusion: High serum OPG as an independent risk factor may contribute to the pathogenesis of atherothrombotic ischemic stroke. | ||||
| Keywords | ||||
| TNF receptor superfamily; ischemic stroke; atherothrombotic | ||||
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