Evaluation of Antioxidant Activity of Cinnamomum glanduliferum Leaf Oil Using Several In-vitro Assays

Zakaria, Gina A.; Mostafa, Nada M.; Abou El-Ezz, Rania F.; Eldahshan, Omayma A.

doi:10.21608/aps.2023.209218.1120

	Evaluation of Antioxidant Activity of Cinnamomum glanduliferum Leaf Oil Using Several In-vitro Assays
Archives of Pharmaceutical Sciences Ain Shams University
Volume 7, Issue 1, June 2023, Page 200-207 PDF (562.3 K)
Document Type: Original Article
DOI: 10.21608/aps.2023.209218.1120
View on SCiNiTO
Authors
Gina A. Zakaria¹; Nada M. Mostafa ²; Rania F. Abou El-Ezz¹; Omayma A. Eldahshan ²
¹Department of Pharmacognosy, Faculty of Pharmacy, Misr International University, Cairo, Egypt.
²Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, Cairo 11566, Egypt.
Abstract
Numerous species of genus Cinnamomum have been utilized in traditional medicine for their diverse range of health benefits. One of the key properties of cinnamon that has gained significant attention in recent years is its antioxidant activity. Numerous well-known cinnamon species have been assessed for their antioxidant properties and have exhibited surprisingly positive results, which has prompted further investigation into the potential antioxidant effects of species that have yet to be studied. Cinnamon is classified as nutraceutical which is a desirable characteristic. In the current study, the essential oil of the leaf of Cinnamomum glanduliferum (Wall.) Nees (Lauraceae) was isolated using Clevenger apparatus and was subjected to GC/MS analysis, enabling the chemical profiling of its constituents. Results revealed that cineole, sabinene, and α-terpineol were identified as the prominent compounds in the oil. Our study aimed at examining antioxidant activity of Cinnamomum glanduliferum through the utilization of three widely recognized antioxidant assays: DPPH assay by comparing IC50 values of oil with trolox as a standard, FRAP assay by comparing ferrous equivalents of oil with that of ascorbic acid, and ORAC assay by comparing IC50 values of oil with quercetin. The results suggest that it may be a promising candidate for further investigation as a potential therapeutic or preventative agent against oxidative stress-related diseases and conditions.
Keywords
Cinnamomum glanduliferum; Leaf; Volatile oil; Anti-oxidant; DPPH; FRAP; ORAC


Statistics Article View: 401 PDF Download: 360