Effect of Xylazine Administration on Ketoprofen Toxicity in Mice | ||||
| Egyptian Journal of Veterinary Sciences | ||||
| Volume 54, Issue 5, September and October 2023, Page 983-996 PDF (3.32 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejvs.2023.204616.1482 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
khalil khalil1; Muna hazim Al-Zubaidy   2; Yaareb Mousa 3
| ||||
| 1Department of Physiology, Biochemistry and Pharmacology, College of Veterinary Medicine, University of Mosul, Mosul, Iraq | ||||
| 2physiology ,biochemistry and pharmacology /university of Mosul /Mosul /Iraq | ||||
| 3Department of Physiology, Biochemistry, and Pharmacology, College of Veterinary Medicine, University of Mosul. | ||||
| Abstract | ||||
| The goal of our study was to assess the influence of xylazine on the toxicity of ketoprofen in mice, then we determined the effect of co-administration of xylazine and ketoprofen on neurobehavioral toxicity and liver and kidney function as well as histopathological effects after repeated daily administration for 20 days. The LD50 of ketoprofen & xylazine were respectively (375mg/kg, 75 mg/kg) respectively. The injection of ketoprofen alone at a dose of (0.126 mg/kg) & ketoprofen & xylazine together at a dose of (0.663 mg/kg) caused the crossed squares & rearing to decline significantly. This was accompanied by a significant increase in the time it took the mouse to return to its normal position and a significant decline in the frequency of head poking. On the tenth and twenty-fifth day of administration of ketoprofen at (71.95 mg/kg) & xylazine at (14.156 mg/kg i.p) there was a significant elevation in the concentration of liver enzymes(AST& ALT) & kidney function (Creatinine and uric acid ), as well as causing histological changes in the liver, kidney & brain. Our findings reveal that the xylazine caused an exacerbation of ketoprofen toxicity which appear as a depressant effect on the CNS , liver and kidney, furthermore histopathological changes in the liver, kidney, and brain. | ||||
| Keywords | ||||
| Ketoprofen; Xylazine; Toxicity; Mice | ||||
|
Statistics Article View: 133 PDF Download: 134 |
||||
