Evaluation of the Level of Type II Collagen C-Terminal Telopeptide in Urine in Patients with Early Knee Osteoarthritis
Atef Yousef, A., Abd Elsalam Hussien Shabana, A., Mofreh Mohamed Salem, M., Abd El Ghafar, D. (2023). Evaluation of the Level of Type II Collagen C-Terminal Telopeptide in Urine in Patients with Early Knee Osteoarthritis. EKB Journal Management System, 29(5), 1365-1374. doi: 10.21608/zumj.2023.221744.2819
Alaa Atef Yousef; Adel Abd Elsalam Hussien Shabana; Mohamed Mofreh Mohamed Salem; Dina Mahmoud Abd El Ghafar. "Evaluation of the Level of Type II Collagen C-Terminal Telopeptide in Urine in Patients with Early Knee Osteoarthritis". EKB Journal Management System, 29, 5, 2023, 1365-1374. doi: 10.21608/zumj.2023.221744.2819
Atef Yousef, A., Abd Elsalam Hussien Shabana, A., Mofreh Mohamed Salem, M., Abd El Ghafar, D. (2023). 'Evaluation of the Level of Type II Collagen C-Terminal Telopeptide in Urine in Patients with Early Knee Osteoarthritis', EKB Journal Management System, 29(5), pp. 1365-1374. doi: 10.21608/zumj.2023.221744.2819
Atef Yousef, A., Abd Elsalam Hussien Shabana, A., Mofreh Mohamed Salem, M., Abd El Ghafar, D. Evaluation of the Level of Type II Collagen C-Terminal Telopeptide in Urine in Patients with Early Knee Osteoarthritis. EKB Journal Management System, 2023; 29(5): 1365-1374. doi: 10.21608/zumj.2023.221744.2819

Evaluation of the Level of Type II Collagen C-Terminal Telopeptide in Urine in Patients with Early Knee Osteoarthritis

Zagazig University Medical Journal
Article 18, Volume 29, Issue 5, September and October 2023, Page 1365-1374  XML PDF (651.94 K)
Document Type: Original Article
DOI: 10.21608/zumj.2023.221744.2819
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Authors
Alaa Atef Yousef email 1; Adel Abd Elsalam Hussien Shabana2; Mohamed Mofreh Mohamed Salem3; Dina Mahmoud Abd El Ghafar4
1Department of Rheumatology and Rehabilitation, Faculty of Medicine Mansoura University.
2Department of Rheumatology and Rehabilitation, Faculty of Medicine Mansoura University.
3Department of Clinical Pathology, Faculty of Medicine -Mansoura University
4Department of Rheumatology and Rehabilitation, Faculty of Medicine- Mansoura University
Abstract
Background: Knee osteoarthritis is a multifactorial disorder that has been identified as a major source of disability. Greater urinary C-telopeptide pieces of type II collagen (UCTXII) amounts were associated with greater activity of the disease scores; thus, the purpose of the present research was to compare urinary CTX-II levels between patients with early KOA and control subjects, as well as to find out the relationship between urinary CTX-II levels, radiographic detection of OA, and outcome reported by patients.

Methods: This study involved 90 people, 45 with osteoarthritis (cases) and 45 healthy people (control group). All patients received a diagnosis with KOA using the 2016 ACR clinical and radiological categorization criteria. Everyone who participated in the study signed a written consent form. We included individuals with Kellgren-Lawrence (KL) grade 0 or 1 knee OA in our study.

Results: There was a statistically significant beneficial relationship among UCTXII and the WOMAC, the visual analogue scale score, C-reactive protein, and the rate of erythrocyte sedimentation at the Western Ontario and McMaster Colleges. There was, however, no substantial link among UCTXII and age or BMI. The optimum Urinary CTXII threshold value for distinguishing osteoarthritis patients from controls was > 85.25. This point demonstrated a high level of sensitivity and specificity, as well as a statistically substantial result.

Conclusion: According to our findings, urine C-telopeptide fragments of type II collagen (UCTXII) constitute an efficient, harmless, and viable method for detecting early knee OA.
Keywords
Western Ontario and McMaster Universities Osteoarthritis Index; Urinary C-Terminal Telopeptide; Type II Collagen
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