Acute Coronary Syndrome: Beyond Conventional Treatment | ||||
| Records of Pharmaceutical and Biomedical Sciences | ||||
| Volume 7, Issue 3, January 2023, Page 134-139 PDF (590.75 K) | ||||
| Document Type: Mini-reviews | ||||
| DOI: 10.21608/rpbs.2023.212085.1227 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Mohamed Ibrahim Ahmed  1; Heba Abdelrazek2; Yasser Moustafa 3; Dina M. Khodeer 4
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| 1Department of Pharmacology and Toxicology, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt | ||||
| 2Professor of Physiology Faculty of Veterinary Medicine Suez Canal University | ||||
| 3Pharmacology and Toxicology Department, Faculty of Pharmacy, Suez Canal University, Ismailia, 41522, Egypt. | ||||
| 4Department of Pharmacology & Toxicology, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt | ||||
| Abstract | ||||
| Acute coronary syndrome, which is the acute manifestation of ischemic heart disease, remains a major cause of morbidity and mortality across the world and is mainly responsible for 1.8 million deaths per year. The pathophysiology of acute coronary syndrome is usually due to atherosclerotic plaque rupture which results in a sequence of inflammatory events, thrombus formation, and platelet aggregation causing an aggravation of insufficient perfusion to meet myocardial oxygen demand which can eventually lead to myocardial infarction. Serotonin a monoamine neurotransmitter and a hormone found in both the central nervous system and the peripheral nervous system is released during myocardial ischemia, acute inflammation, and tissue damage leading to platelets aggregation, thrombus formation, contraction of smooth muscle cells, and coronary artery spasms. Serotonin also plays an important role in the progression of myocardial cellular injury through various pathways. This review discusses the potential therapeutic role of targeting the serotonin system in the setting of acute coronary syndrome. | ||||
| Keywords | ||||
| Heart; Ischemic heart disease; Acute coronary syndrome; Myocardial infarction; Serotonin | ||||
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