In Vitro Effiacy Of Different Antibiotic Combinations On Aminoglycoside-Resistant Acinetobacter Baumannii
Ibrahim, S., abdelhamid, F., salah, N., elsayed, M. (2019). In Vitro Effiacy Of Different Antibiotic Combinations On Aminoglycoside-Resistant Acinetobacter Baumannii. EKB Journal Management System, 36(1), 49-65. doi: 10.21608/jsrs.2019.30997
Sarah Ibrahim Saad Ibrahim; Ferialla abdelhamid; Neveen Mohamed salah; Mohamed elsayed. "In Vitro Effiacy Of Different Antibiotic Combinations On Aminoglycoside-Resistant Acinetobacter Baumannii". EKB Journal Management System, 36, 1, 2019, 49-65. doi: 10.21608/jsrs.2019.30997
Ibrahim, S., abdelhamid, F., salah, N., elsayed, M. (2019). 'In Vitro Effiacy Of Different Antibiotic Combinations On Aminoglycoside-Resistant Acinetobacter Baumannii', EKB Journal Management System, 36(1), pp. 49-65. doi: 10.21608/jsrs.2019.30997
Ibrahim, S., abdelhamid, F., salah, N., elsayed, M. In Vitro Effiacy Of Different Antibiotic Combinations On Aminoglycoside-Resistant Acinetobacter Baumannii. EKB Journal Management System, 2019; 36(1): 49-65. doi: 10.21608/jsrs.2019.30997

In Vitro Effiacy Of Different Antibiotic Combinations On Aminoglycoside-Resistant Acinetobacter Baumannii

Journal of Scientific Research in Science
Article 4, Volume 36, Issue 1, April 2019, Page 49-65  XML PDF (793.73 K)
Document Type: Original Article
DOI: 10.21608/jsrs.2019.30997
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Authors
Sarah Ibrahim Saad Ibrahim email 1; Ferialla abdelhamid1; Neveen Mohamed salah2; Mohamed elsayed3
1Assistant Prof. of Microbiology Botany and Microbiology deparment ,faculty for wamen for arts.Scinces and Education –Ain Shams Univerisity.
2Assistant Prof. of Microbiology,Microbiology deparment ,National Organization for Drug Control and Research (NODCAR).
3Assistant Prof. of Microbiology,Microbiology deparment ,National Organization for Biological Control and Research (NODCAR).
Abstract
The potential synergy of combination of β-lactams(ceftriaxone, cefixime, carpabenem, and impenim)and aminoglycosides were tested against multidrug resistant Acinetobacter baumannii. Two-hundred bacterial pathogens were collected from Egyptian hospitals from various infection sites.One hundred and twentytwo isolates (60%) were resistant for aminoglycosides.Out of two-hundred strains,130 Acinetobacter baumannii strains (65%), were impenim resistant and nearly 180 Acinetobacter baumannii strains (90%),were resistant to cephalosporin. The MIC was determined for Acinetobacter baumanni istrains(32 to >512 mg/ml). In the checkerboard method, 38 combination from 45 combinations showed synergism for more than60% of the tested strains but only two  demonstrated antagonism against 5 of tested strains. i.e. the ratio of synergy were detected for gentamycin with impenim, ceftriaxone and cefixime was 100%. Also synergism observed in case of combination between amakacin and tobramycin with ceftriaxone and cefixine with 100%,but in case of combination of tobramycin with imipenem showed ratio of synergy is 50% Whereas, combination between amakacin/impenim showed antagonism .
 
Keywords
Acinetobacter baumannii; Aminoglycosides; β-lactams combination. Synergy
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