Eco-friendly Synthesis Of Zinc Oxide Nanoparticles by Garcinia cambogia and Evaluation of Their Obesity and Antimicrobial Activities | ||||
| Egyptian Journal of Chemistry | ||||
| Volume 67, Issue 2, February 2024, Page 17-27 PDF (934.47 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejchem.2023.212794.8008 | ||||
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| Authors | ||||
AMANI M.D EL-MESALLAMY 1; Ahmed khaled Alahwany1; Mohamed I.M El-Zaidy 1; Sahar Awad Allah Hussein  2
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| 1Department of Chemistry, Faculty of Science, Zagazig University, Zagazig, 44519, Egypt | ||||
| 2Department of Phytochemistry and Plant Systematics, Division of Pharmaceutical Industries, National Research Center, El Buhouth st., Dokki Dokki, Cairo, Egypt | ||||
| Abstract | ||||
| In the present synthesis, study of nanoparticles of zinc oxide using ethanolic extract of Garcinia cambogia leaves extract. Using of zinc oxide nanoparticles as a precursor in leaf extracts of this plant for NPs synthesis. The optical properties and structural of NPs were investigated by ultraviolet-visible(UV-Vis) spectrophotometer ,scanning electron microscope (SEM), transmission electron microscopy (TEM) and dynamic light scattering (DLS). Liquid Chromatography-Electrospray Ionization-Mass (LC-ESI-Mass) in negative ion mode of ethanolic extract demonstrates the presence of six bioactive compounds identified as guanosine, prephenic acid, tetrahydroxy-cholanic acid, limocitrin, 6,7-dihydroxycoumarin-6-glucoside and hydroxy citric acid which they responsible for providing electrons for reducing zinc nitrate hexahydrate to ZnO-NPs. The antibacterial activity of both ethanolic extract and eco-friendly synthesis Of ZnO-NPs. by G.cambogia were tested against two pathogenic bacterial strains (Staphylococcus aureus ATCC6538 and Escherichia coli ATCC10536 ) by using disk diffusion method. The ZnO-NPs showed antibacterial activity against S. aureus (40 mm) more than ethanolic extract (35 mm). The ZnO-NPs revealed significant antibacterial activity against E. coli (50 mm) compared to ethanolic extract (45 mm). Also, ZnO-NPs displayed more antibacterial activity than Ampicillin against S. aureus (266.6%) and E. coli (500%) and displayed more antifungal activity than Fluconazole against C. albicans (238.6%). However, ZnO-NPs showed higher antifungal activity against C.albicans (50.11 mm) than the ethanolic extract (45.37 mm). Based on these findings, it is concluded that the synthesized ZnO-NPs is a more promising candidate than the alcoholic extract of G. Cambogia leaves against pathogenic bacterial, fungal strains. The administration of G. cambogia and synthesized ZnO-Nps as a weight-reduction treatment is intended to give the important knowledge for both scholarly and broad public use regarding the effects of the plant. | ||||
| Keywords | ||||
| Garcinia cambogia; eco-friendly synthesis; ZnO-NPs; LC-ESI-Mass analysis; antimicrobial activity; Obesity | ||||
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