In Vitro Assessment of Antioxidant and Cytotoxic Activities of Zygophyllum coccineum L. Methanolic Extract
El-Afify, S., El-Metwaly, M., Abbas, M., El-Amier, Y. (2024). In Vitro Assessment of Antioxidant and Cytotoxic Activities of Zygophyllum coccineum L. Methanolic Extract. EKB Journal Management System, 67(2), 393-401. doi: 10.21608/ejchem.2023.214820.8070
Shahenda M. El-Afify; Mohammed A. El-Metwaly; Mohammed A. Abbas; Yasser A. El-Amier. "In Vitro Assessment of Antioxidant and Cytotoxic Activities of Zygophyllum coccineum L. Methanolic Extract". EKB Journal Management System, 67, 2, 2024, 393-401. doi: 10.21608/ejchem.2023.214820.8070
El-Afify, S., El-Metwaly, M., Abbas, M., El-Amier, Y. (2024). 'In Vitro Assessment of Antioxidant and Cytotoxic Activities of Zygophyllum coccineum L. Methanolic Extract', EKB Journal Management System, 67(2), pp. 393-401. doi: 10.21608/ejchem.2023.214820.8070
El-Afify, S., El-Metwaly, M., Abbas, M., El-Amier, Y. In Vitro Assessment of Antioxidant and Cytotoxic Activities of Zygophyllum coccineum L. Methanolic Extract. EKB Journal Management System, 2024; 67(2): 393-401. doi: 10.21608/ejchem.2023.214820.8070

In Vitro Assessment of Antioxidant and Cytotoxic Activities of Zygophyllum coccineum L. Methanolic Extract

Egyptian Journal of Chemistry
Volume 67, Issue 2, February 2024, Page 393-401  XML PDF (613.06 K)
Document Type: Original Article
DOI: 10.21608/ejchem.2023.214820.8070
View on SCiNiTO View on SCiNiTO
Authors
Shahenda M. El-Afify email 1; Mohammed A. El-Metwaly2; Mohammed A. Abbas1; Yasser A. El-Amier1
1Botany Department, Faculty of Science, Mansoura University, Mansoura, Egypt
2Research Institute of Plant Pathology, Agriculture Research Center, Egypt
Abstract
Zygophyllum coccineum is a halophytic plant species that belongs to the Zygophyllaceae family and can survive in high-salted and coastal-land areas. The present study intends to identify Z. coccineum extract. GC/MS spectral analysis was used to characterize the volatile components of the plant extract and estimate their biological profiles. From the methanol extract of Z. coccineum, six components were discovered by GC-MS analysis, with 2-ethylhexanoic acid is the major volatile component with (82.98%) of total composition. It was found that 91b,5,5,6a-tetramethyl-octahydro-1-ox a-cyclopropane[a]inden-6-one had a high composition percentage (8.13%) in the terpene category, and 6H-[1]benzopyrano[4,3-C]isoquinoline-6,11(5H)-dione was found by composition percentage (2.90%) from the category of alkaloid. When evaluated for DPPH antioxidant activity, at 1000 mg/ml, the scavenging activities of 61.89 for Z. coccineum extract. However, the samples with the lowest concentration (100 mg/ml) demonstrate the weakest antioxidant activity overall. With IC50 values of 5.24, 8.80, and >100 g ml-1 for HepG-2, PC3, and WI-38, respectively, the 50% methanol extract of Z. coccineum demonstrated an enhanced potential anticancer impact and significant cytotoxicity for the two tumor cells. As a result, the biological activity of Z. coccineum supports its use as a traditional therapy for a variety of diseases, including cancer treatment.
Keywords
Zygophyllum coccineum; Antioxidant activity; GCMS; tumor cells
Statistics
Article View: 86
PDF Download: 91