Spectroscopic studies and antibacterial activities of 11H-indeno [1,2-b] quinoxaline-11-one
Onsy, D., Metwally, H., Elsayed, A. (2024). Spectroscopic studies and antibacterial activities of 11H-indeno [1,2-b] quinoxaline-11-one. EKB Journal Management System, 67(2), 563-570. doi: 10.21608/ejchem.2023.213593.8028
Dalia S. Onsy; Heba M. Metwally; Ashraf Elsayed. "Spectroscopic studies and antibacterial activities of 11H-indeno [1,2-b] quinoxaline-11-one". EKB Journal Management System, 67, 2, 2024, 563-570. doi: 10.21608/ejchem.2023.213593.8028
Onsy, D., Metwally, H., Elsayed, A. (2024). 'Spectroscopic studies and antibacterial activities of 11H-indeno [1,2-b] quinoxaline-11-one', EKB Journal Management System, 67(2), pp. 563-570. doi: 10.21608/ejchem.2023.213593.8028
Onsy, D., Metwally, H., Elsayed, A. Spectroscopic studies and antibacterial activities of 11H-indeno [1,2-b] quinoxaline-11-one. EKB Journal Management System, 2024; 67(2): 563-570. doi: 10.21608/ejchem.2023.213593.8028

Spectroscopic studies and antibacterial activities of 11H-indeno [1,2-b] quinoxaline-11-one

Egyptian Journal of Chemistry
Volume 67, Issue 2, February 2024, Page 563-570  XML PDF (798.28 K)
Document Type: Original Article
DOI: 10.21608/ejchem.2023.213593.8028
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Authors
Dalia S. Onsy1; Heba M. Metwally2; Ashraf Elsayed email 3
1Botany Department, Faculty of Science, Mansoura University, Elgomhouria St., Mansoura 35516, Egypt;
2Chemistry Department, Faculty of Science, Mansoura University, Elgomhouria St., Mansoura 35516, Egypt;
3Botany department, Faculty of Science, Mansoura University
Abstract
Morbidity and mortality induced by bacterial infection are significant health problems. To take over this challenge, new antibacterial agent discovery is a must. In this work, 11H-indeno[1,2-b]quinoxaline-11-one was chemically synthesized, and its biological activities were evaluated against Salmonella typhimurium (S. typhi), Klebsiella pneumoniae (K. pneumoniae), and Bacillus subtilis (B. subtilis). The biological activity of the compound was studied by a well diffusion method besides minimum inhibitory concentration (MIC), and resistant development evaluation. Optimization of the geometric structure was performed using DFT calculation and a comparison between calculated and experimental geometric structures and spectral data using the function BLY3P/6-311++G(d,p). MIC values against S. typhi, K. pneumoniae, and B. subtilis were recorded as values of 10, 20, and 20 mM respectively. Within seven days, none of these bacteria have no resistance against the tested compound at 1, 2, 3, and 4x MIC concentrations. The comparison between optimized structures geometry and spectral data (1HNMR and 13CNMR) with experimental data displayed acceptable agreement. Eventually, 11H-indeno[1,2-b]quinoxaline-11-one could be recommended as an effective antibacterial agent.
Keywords
11H-indeno[1,2-b]quinoxaline-11-one; S. typhi; B. sibtilis; K. pneumoniae; resistant development; spectral analysis
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