Interleukin 36α Serum Level in Egyptian Patients with Systemic Lupus Erythematosus and its relation to Disease Activity
Tantawy, M., Abd-ElAzeem, M., Mohamed, A., Altememy, R., Fathy, H. (2023). Interleukin 36α Serum Level in Egyptian Patients with Systemic Lupus Erythematosus and its relation to Disease Activity. EKB Journal Management System, 4(3), 24-38. doi: 10.21608/ejmr.2023.218599.1409
Marwa Tantawy; Mervat Ismail Abd-ElAzeem; Asmaa Ibrahem Mohamed; Rabab Afify Altememy; Hossam Marouf Fathy. "Interleukin 36α Serum Level in Egyptian Patients with Systemic Lupus Erythematosus and its relation to Disease Activity". EKB Journal Management System, 4, 3, 2023, 24-38. doi: 10.21608/ejmr.2023.218599.1409
Tantawy, M., Abd-ElAzeem, M., Mohamed, A., Altememy, R., Fathy, H. (2023). 'Interleukin 36α Serum Level in Egyptian Patients with Systemic Lupus Erythematosus and its relation to Disease Activity', EKB Journal Management System, 4(3), pp. 24-38. doi: 10.21608/ejmr.2023.218599.1409
Tantawy, M., Abd-ElAzeem, M., Mohamed, A., Altememy, R., Fathy, H. Interleukin 36α Serum Level in Egyptian Patients with Systemic Lupus Erythematosus and its relation to Disease Activity. EKB Journal Management System, 2023; 4(3): 24-38. doi: 10.21608/ejmr.2023.218599.1409

Interleukin 36α Serum Level in Egyptian Patients with Systemic Lupus Erythematosus and its relation to Disease Activity

Egyptian Journal of Medical Research
Volume 4, Issue 3, July 2023, Page 24-38  XML PDF (521.67 K)
Document Type: Original Article
DOI: 10.21608/ejmr.2023.218599.1409
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Authors
Marwa Tantawyorcid 1; Mervat Ismail Abd-ElAzeem2; Asmaa Ibrahem Mohamed2; Rabab Afify Altememy3; Hossam Marouf Fathy email 2
1Rheumatology, Faculty of Medicine, Beni-Suef University, Egypt
2Rheumatology and Rehabilitation faculty of medicine Beni-Suef university Beni-Suef Egypt
3Clinical Pathology Department, faculty of medicine Beni-Suef university Beni-Suef Egypt
Abstract
Background:  Systemic lupus erythematosus (SLE) is a systemic illness marked by clinical variability, unpredictable outcome, and recurring flares. Interleukin 36α is crucial for innate immunity. It is strongly hypothesized that IL-36 has an impact on SLE pathogenesis. Aim: Assessing the link between interleukin 36α levels and disease activity in systemic lupus erythematosus (SLE). Subjects and Methods: This study examined forty systemic lupus erythematosus patients and 40 controls. The SLE disease activity index (SLEDAI) establishes disease activity. ELISA estimates serum Interleukin 36α.  Results: Interleukin 36 α levels were considerably higher in SLE patients compared with the controls (P < 0.001). IL-36α levels significantly linked to the SLE disease activity index (SLEDAI) score (P <0.001), age (P = 0.002), disease duration (P = 0.00), arthritis (P <0.001), nephritis (P = 0.002), and anti-double-stranded DNA antibody (P <0.001). IL-36 α levels and complement 3 were inversely linked (P < 0.001).  Conclusion: Interleukin 36α may identify SLE activity early in follow-up.
Keywords
Interleukin 36α (IL-36α); Systemic lupus erythematosus (SLE); SLE disease activity index (SLEDAI)
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