Evaluation of the Curcumin role against cytotoxicity of cadmium chloride in mice | ||||
| Bulletin of Faculty of Science, Zagazig University | ||||
| Article 14, Volume 2016, Issue 1, 2020, Page 175-186 PDF (336.45 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bfszu.2016.31074 | ||||
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| Abstract | ||||
| The present study was aimed to evaluate the role of curcumin (CMN) against cytotoxicity of cadmium chloride. Thirty adult male albino mice 3 months old and20-25 grams body weight, were caged into six equal groups. Mice were injected, i.p with 50 mg CMN/kg and/or 0.67 mg CdCl2/kg b.w for 96h, separately and alternated. The alternated trials were continued for consecutive 8 days. Results appeared that mice injected with cadmium had significant higher frequency of chromosomal aberrations as fragments, centric fusion, gaps, stickiness and aneuploidy. Also, CdCl2 appeared sperm hummer, without hook, banana and amorphous abnormalities. The administration of CMN improved the frequency of the chromosomal aberrations and sperm abnormalities induced by CdCl2. The administration of CMN after CdCl2 protects the body from cytotoxicity arising from CdCl2 as well as normal sperm values were recorded. The administration of curcumin before CdCl2 injection did not improve the CdCl2 effect. It could be concluded that the employed dose of CMN protects the body from cytotoxicity arising. | ||||
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