Rotavirus structure, genomics, types, pathophysiology and prevention: Review Article

Azzazy, Ensaf Abd-El Gawad; Abdellatif, Ghada Mohammed; Abd-ElMoneim Mohamed, Hala Adel; Abo-Alella, Doaa Alhussein

doi:10.21608/zumj.2023.224421.2831

	Rotavirus structure, genomics, types, pathophysiology and prevention: Review Article
Zagazig University Medical Journal
Article 2, Volume 30, Issue 1.6, September 2024, Page 2687-2692 PDF (815.01 K)
Document Type: Review Articles
DOI: 10.21608/zumj.2023.224421.2831
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Authors
Ensaf Abd-El Gawad Azzazy¹; Ghada Mohammed Abdellatif²; Hala Adel Abd-ElMoneim Mohamed ³; Doaa Alhussein Abo-Alella ¹
¹Medical Microbiology &Immunology Department, Faculty of Medicine, Zagazig University
²Pediatrics Department, Faculty of Medicine, Zagazig University
³Medical Microbiology &amp;amp;Immunology Department, Faculty of Medicine, Zagazig University
Abstract
Children under the age of five are most commonly affected by severe, dehydrating gastroenteritis brought on by infections with rotavirus. Despite the common usage of rotavirus immunizations more than ten years ago, rotavirus infections still cause more than 200,000 fatalities each year, primarily in developing nations. Rotavirus predominantly affects enterocytes and causes diarrhoea by destroying absorbent enterocytes (resulting in malabsorption), stimulating intestinal secretion with activating the enteric nervous system, and viral non-structural protein 4. Furthermore, rotavirus infections can result in viremia and antigenaemia, both of which are connected to more severe acute gastroenteritis symptoms. Although this is uncommon, rotavirus can also replicate in systemic areas. Rotavirus reactivations are frequent throughout life, however they lessen the severity of the illness. Although both aspects—protection against rotavirus reinfection and recovery from infection—involve rotavirus-specific immunoglobulin A, the immunological implications of these processes are poorly understood. Although the use of antiviral and antiemetic medications may be necessary in rare circumstances, Dehydration must be avoided and treated in order to manage rotavirus infection.
Keywords
Rotavirus structure; pathophysiology; management; Lanzhou Lamb Rotavirus; triple-layered particle


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