Association of Human Leukocyte Antigen-G Gene Polymorphisms with Rheumatoid Arthritis: Relationship with Disease Activity, Severity and Treatment Response
Fathi, S., Seleim, H., Hammad, M., Ezzeldin, N., Pasha, H. (2024). Association of Human Leukocyte Antigen-G Gene Polymorphisms with Rheumatoid Arthritis: Relationship with Disease Activity, Severity and Treatment Response. EKB Journal Management System, 30(1.3), 248-258. doi: 10.21608/zumj.2023.223381.2826
Shimaa Elsayed Fathi; Heba Seleim; Marwa Hammad; Nillie Ezzeldin; Heba Pasha. "Association of Human Leukocyte Antigen-G Gene Polymorphisms with Rheumatoid Arthritis: Relationship with Disease Activity, Severity and Treatment Response". EKB Journal Management System, 30, 1.3, 2024, 248-258. doi: 10.21608/zumj.2023.223381.2826
Fathi, S., Seleim, H., Hammad, M., Ezzeldin, N., Pasha, H. (2024). 'Association of Human Leukocyte Antigen-G Gene Polymorphisms with Rheumatoid Arthritis: Relationship with Disease Activity, Severity and Treatment Response', EKB Journal Management System, 30(1.3), pp. 248-258. doi: 10.21608/zumj.2023.223381.2826
Fathi, S., Seleim, H., Hammad, M., Ezzeldin, N., Pasha, H. Association of Human Leukocyte Antigen-G Gene Polymorphisms with Rheumatoid Arthritis: Relationship with Disease Activity, Severity and Treatment Response. EKB Journal Management System, 2024; 30(1.3): 248-258. doi: 10.21608/zumj.2023.223381.2826

Association of Human Leukocyte Antigen-G Gene Polymorphisms with Rheumatoid Arthritis: Relationship with Disease Activity, Severity and Treatment Response

Zagazig University Medical Journal
Article 30, Volume 30, Issue 1.3, March and April 2024, Page 248-258  XML PDF (1.13 MB)
Document Type: Original Article
DOI: 10.21608/zumj.2023.223381.2826
View on SCiNiTO View on SCiNiTO
Authors
Shimaa Elsayed Fathi email orcid 1; Heba Seleimorcid 2; Marwa Hammadorcid 3; Nillie Ezzeldinorcid 4; Heba Pashaorcid 5
1Rheumatology, rehabilitation and physical medicine department, Faculty of medicine, Port Said University, Egypt.
2Rheumatology& Rehabilitation Department, Faculty of Medicine, Zagazig University, Egypt.
3Rheumatology and Rehabilitation Faculty of medicine
4Rheumatologically and rehabilitation Diseases Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt
5Biochemistry Department, Faculty of Medicine, Zagazig University, Egypt.
Abstract
Rheumatoid arthritis (RA) may be impacted by HLA-G gene variation. In a group of Egyptian RA patients, this study sought to determine the effects of the polymorphisms +3142G>C and 14 bp ins/del on disease susceptibility, activity, severity, and response to treatment. Methods: This case-control study was done on 75 patients with RA and 75 healthy subjects. The HLA-G rs1063320 (+3142G>C) and rs66554220 14 bp insertion (ins)/deletion (del) variants were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFP) and PCR method, respectively. Results: Our finding didn't support an association between HLA-G 14 bp ins/del or the HLA-G +3142G>C variants and RA susceptibility. The G allele of HLA-G +3142G>C was significantly associated with the presence of subcutaneous nodules and longer morning stiffness. The GG genotype and the G allele of HLA-G +3142G>C were shown to be a risk factor for higher C-reactive protein (CRP) and autoantibodies production [anti-citrullinated protein antibodies (ACPA) and ACPA+ rheumatoid factor (RF)].The HLA-G+3142G>C polymorphism was found to be associated with RA severity (higher rheumatoid arthritis severity scale ,RASS, scores). Conclusion: The 14 bp ins/del and the +3142G>C of HLA-G gene didn’t appear to be associated with RA susceptibility in this studied group of RA patients, but may act as a genetic modifier of disease phenotype in terms of autoantibody production, severity, clinical phenotype and treatment response. In this sense, we suggest that these polymorphisms act as a disease modifier rather than a risk factor for development of RA.
Keywords
Egyptian; genetic; polymorphisms; human leukocyte antigen-G; rheumatoid arthritis
Statistics
Article View: 60
PDF Download: 2