Increased LncRNA TUG1 expression level impacted ankylosing spondylitis risk, association with disability, and patients’ quality of life
Tawfeek, G., esaily, H., Fetoh, D. (2023). Increased LncRNA TUG1 expression level impacted ankylosing spondylitis risk, association with disability, and patients’ quality of life. EKB Journal Management System, (), -. doi: 10.21608/mxe.2023.200000.1000
Gehan Tawfeek; Heba esaily; Dina Fetoh. "Increased LncRNA TUG1 expression level impacted ankylosing spondylitis risk, association with disability, and patients’ quality of life". EKB Journal Management System, , , 2023, -. doi: 10.21608/mxe.2023.200000.1000
Tawfeek, G., esaily, H., Fetoh, D. (2023). 'Increased LncRNA TUG1 expression level impacted ankylosing spondylitis risk, association with disability, and patients’ quality of life', EKB Journal Management System, (), pp. -. doi: 10.21608/mxe.2023.200000.1000
Tawfeek, G., esaily, H., Fetoh, D. Increased LncRNA TUG1 expression level impacted ankylosing spondylitis risk, association with disability, and patients’ quality of life. EKB Journal Management System, 2023; (): -. doi: 10.21608/mxe.2023.200000.1000

Increased LncRNA TUG1 expression level impacted ankylosing spondylitis risk, association with disability, and patients’ quality of life

Middle East Journal of Medical Genetics
Articles in Press, Accepted Manuscript, Available Online from 10 August 2023  XML
Document Type: Original Article
DOI: 10.21608/mxe.2023.200000.1000
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Authors
Gehan Tawfeek email 1; Heba esaily2; Dina Fetoh2
1Clinical pathology department, faculty of medicine, menoufia univerisity
2physical Medicine, Rheumatology and Rehabilitation Department, Faculty of Medicine, Menoufia University, Egypt
Abstract
Studying of LncRNA TUG1 expression level as a risk of AS development is unclear, in addition to its relation to disability & quality of life which has not been studied before. In the present study, 50 cases of AS with 50 healthy controls of matched age and gender were included. Patients were split into two groups based on BASDAI: active AS patients and inactive AS cases. For AS patients, disease duration, clinical assessment, Quality of life was assessed using ASQoL, Mobility and functional limitations were assessed by BASMI and BASFI scores. Structural damage was assessed using MSASSS. Full laboratory investigations were done including: HLA-B27, ESR and CRP, Vitamin D levels by enzyme immunoassay method and measurement of LncRNA TUG1 by quantitative real time PCR (qRT-PCR). There was Upregulation of LncRNA TUG1 in AS patients than control (p<0.001), at cutoff >6.2 TUG1 has sensitivity 88% and specificity 84%. active AS patients have significant higher level of LncRNA TUG1 than inactive AS (p<0.001) with sensitivity 84% & specificity 88%. Also, TUG1 could discriminate AS with structural damage from those without structural damage (p=0.008). LncRNA TUG1 was positively correlated with CRP, BASDAI, VAS, BASDAI, BASMI, BASFI and MSASSS (p<0.001) and not correlated with disease duration, ESR, Vit D or HLA-B27 (p> 0.05). These results indicated that for the first time, up regulation of LncRNA TUG1 increased the risk of AS and associated with increased disease activity, structural damage, disability and poor quality of life.
Keywords
Ankylosing spondylitis; LncRNA TUG1 gene expression; disease activity; disability; Quality of life
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