Protein and Peptide-based Nanoparticles as an emerging strategy to tackle cancer drug resistance
Abdellatif, M., Hassanin, I., Mahmoud, Y., Teleb, M., Bekhit, A., Khattab, S. (2023). Protein and Peptide-based Nanoparticles as an emerging strategy to tackle cancer drug resistance. EKB Journal Management System, 1(1), 1-21. doi: 10.21608/ajst.2023.206740.1008
Mohamed Khaled Abdellatif; Islam Hassanin; Yosra Saeed Mahmoud; Mohamed Teleb; Adnan A. Bekhit; Sherine N. Khattab. "Protein and Peptide-based Nanoparticles as an emerging strategy to tackle cancer drug resistance". EKB Journal Management System, 1, 1, 2023, 1-21. doi: 10.21608/ajst.2023.206740.1008
Abdellatif, M., Hassanin, I., Mahmoud, Y., Teleb, M., Bekhit, A., Khattab, S. (2023). 'Protein and Peptide-based Nanoparticles as an emerging strategy to tackle cancer drug resistance', EKB Journal Management System, 1(1), pp. 1-21. doi: 10.21608/ajst.2023.206740.1008
Abdellatif, M., Hassanin, I., Mahmoud, Y., Teleb, M., Bekhit, A., Khattab, S. Protein and Peptide-based Nanoparticles as an emerging strategy to tackle cancer drug resistance. EKB Journal Management System, 2023; 1(1): 1-21. doi: 10.21608/ajst.2023.206740.1008

Protein and Peptide-based Nanoparticles as an emerging strategy to tackle cancer drug resistance

Alexandria Journal of Science and Technology
Volume 1, Issue 1, June 2023, Page 1-21  XML PDF (2.12 MB)
Document Type: Review Article
DOI: 10.21608/ajst.2023.206740.1008
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Authors
Mohamed Khaled Abdellatif1; Islam Hassanin email orcid 2; Yosra Saeed Mahmoud2; Mohamed Teleb3; Adnan A. Bekhit4; Sherine N. Khattaborcid 5
1Department of Industrial Pharmacy, Faculty of Pharmacy, Alexandria University, Alexandria, 21521, Egypt
2Department of Biotechnology, Institute of Graduate Studies and Research (IGSR), Alexandria University, Alexandria, 21526, Egypt.
3Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria, 21521, Egypt
4University of Bahrain, Sakhir, Bahrain
5Chemistry Department, Faculty of Science, Alexandria University, Egypt
Abstract
Cancer treatment has been confronted with serious challenges. These challenges stemmed from the heterogeneity of tumor microenvironment, as well as genetic and epigenetic factors related to cancer cells. The changes imposed by the tumor lead to the development of acquired resistance. Drug efflux, inhibition of apoptosis, immunosuppression are examples of resistance mechanisms imposed by cancer cells. Nanotechnology has sought to overcome these resistance mechanisms through enhanced cellular uptake, activation of alternative pathways by combined drug delivery, or targeting immune cells leading to their activation and proliferation. Several types of nanomedicine-based systems were implemented; however, protein and peptide nanoparticles remain one versatile tool in drug delivery, providing preferable physicochemical and biological implications. Notably, protein and peptide nanocarriers can also exhibit enhanced cellular uptake, the possibility of tuned drug release, and hence, better tumor targetability. Here, we present the methods of fabrication, physicochemical characteristics, biological implications, and future perspectives, focusing on overcoming cancer drug resistance.
Keywords
Proteins; peptides; nanoparticles; tumor; cancer drug resistance
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