TAMOXIFEN VERSUS PRAZIQUANTEL IN TREATING SCHISTOSOMIASIS MANSONI IN EXPERIMENTAL INFECTED ALBINO MICE | ||||
| Journal of the Egyptian Society of Parasitology | ||||
| Article 3, Volume 53, Issue 2, August 2023, Page 211-218 PDF (1020.48 K) | ||||
| DOI: 10.21608/jesp.2023.312097 | ||||
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| Authors | ||||
| ADEL OMAR HAFEZ1; AHMED M. A. MOHAMED1; MOHAMMED YOUSSEF SHAKRA2 | ||||
| 1Department of Medical Parasitology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt | ||||
| 2Department of Medical Parasitology, Faculty of Medicine, Al-Azhar University Damietta, Egypt | ||||
| Abstract | ||||
| Schistosomiasis is blood-dwelling parasites of the genus Schistosoma, mainly S. mansoni, S. japonicum and S. haematobium. Praziquantel® (PZQ) is the drug of choice for treatment but, its efficacy decreased as drug resistant strains emerged due to widespread usages. This study assessed the in-vivo anti-schistosomal effects of Tamoxifen® (TAM) compared to praziquantel on experimental S. mansoni-infected mice regarding worm burden, liver enzymes status, cytokines change, histopathological study and the activities of some antioxidants. Mice were infected by ~80±10 cercariae followed by a single oral dose with either praziquantel or tamoxifen 42 days post-infection. The treated mice showed a reduction in worm burden, a decrease in egg load in liver and intestine, a decrease in levels of AST, ALT, interferon-gamma, interleukin 4, and interleukin 10 but, with a significant activities increase of superoxide dismutase (SOD), glutathiones- transferase (GST), glutathione peroxidase (GPx) and Catalase (CAT) and decrease in granuloma size than infected non-treated mice | ||||
| Keywords | ||||
| Schistosoma mansoni; Praziquantel; Tamoxifen; Evaluation | ||||
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