ASSESSMENT OF METHANOLIC PLANT EXTRACT OF ALHAGI MAURORUM IN TREATING TRICHINELLA SPIRALIS INFECTIED MICE | ||||
| Journal of the Egyptian Society of Parasitology | ||||
| Article 14, Volume 53, Issue 2, August 2023, Page 307-314 PDF (2.36 MB) | ||||
| DOI: 10.21608/jesp.2023.312131 | ||||
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| Authors | ||||
| HAGER F. A. SAAD; MOHAMED FATHY ABOUEL-NOUR HEGAZY; DINA M. M. EL-SHEWEHY | ||||
| Department of Zoology, Faculty of Science, Mansoura University, Mansoura, Dakahlia Governorate, Egypt | ||||
| Abstract | ||||
| Trichinella spiralis is a recurrent parasite that infects people everywhere. This work compared the usage of methanolic extract of Alhagi maurorum versus Albendazole in treating trichinellosis in experimental infected mice. Mice (72) were divided in to six groups: CN: Negative control (non-infected-untreated), C-Alb: Mice treated with albendazole but not infected, C-Alhag: Mice treated with methanolic extract of Alhagi, but not infected, CI: Positive control (infected, not treated), T-Alb: Mice were infected then treated with Albendazole, T-Alhag: mice were infected then treated with methanolic extract of A. maurorum. Mice were infected orally with T. spiralis larvae at a dose of 300 larvae/ mouse except control untreated groups. On 7th day post infection half of the groups were sacrificed for intestinal phase and the second half were sacrificed on t 35th day post infection for the muscular phase. Treatment efficacy was determined by parasitological and immunological parameters. The results showed that A. maurorum treated mice gave lowest number of T. spiralis. The counts of adult in intestine and larval in muscle, and immunologic data showed lowest levels of IFN-γ, TNF-α, TGF-β, IL-4, IL-2 & IL-12 and highest level of IL-10 than infected control mice. | ||||
| Keywords | ||||
| Trichinosis; Albendazole; Alhagi maurorum; IFN-γ; TNF-α; TGF-β; IL4; IL10 | ||||
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