Efficacy of aluminum potassium sulfate against Staphylococcus species in wound infections compared to meropenem and amoxyclav | ||||
| Microbes and Infectious Diseases | ||||
| Articles in Press, Accepted Manuscript, Available Online from 14 August 2023 PDF (627.66 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/mid.2023.225605.1574 | ||||
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| Authors | ||||
Ali Abedulameer Alhusayni1; Falah Hasan Obayes AL-Khikani   2
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| 1Department of Microbiology, Al-Shomali General Hospital, Babylon Health Directorate, Babylon, Iraq | ||||
| 2Department of Microbiology, Al-Shomali General Hospital, Babylon Health Directorate, Babylon, Iraq. Department of Medical Laboratory Technology, College of Medical Technology, The Islamic University, Najaf, Iraq | ||||
| Abstract | ||||
| Background: The worldwide increase in multidrug resistance of pathogenic bacteria has led to an urgent need for identifying an alternative strategy. Natural products have been used for centuries in treating human diseases and they contain components of therapeutic value. Alum has become a favorite antimicrobial against bacteria. Material and Methods: Staphylococcus species isolated from wounds in sixty Iraqi patients, isolates were cultured for overnight on blood agar, then were sub-cultured on Mannitol Salt Agar to distinguish between different species. Biochemical tests were done for these bacteria. Well diffusion method for antimicrobial sensitivity used to evaluate 20% aluminum potassium sulfate (alum) activity. Antibacterial activity of meropenem and amoxyclav was assessed by disk diffusion method. Results: The total number of isolated staphylococcus species were 60 including 30 Staphylococcus aureus and 30 coagulase negative staphylococci. The antibacterial activity of 20% alum was 100 % active against all staphylococcus species, while 83.3% and 78.3% of isolates were sensitive to meropenem and amoxyclav respectively. The comparison of the mean of inhibition zone diameter between S. aureus (29.23± 5.39) mm with Coagulase negative staphylococcus (30.2± 3.88) mm showed no significant differences (p= 0.42). Twenty percent of alum (29.5± 5.3) mm is more effective than meropenem (26.1± 5.8) mm significantly (p= 0.02). Alum (29.5± 5.3) mm was significantly more effective than amoxyclav (20.2± 3.9) mm (p <0.001). Conclusion: 20% alum is more effective (superior) than meropenem and amoxyclav against staphylococcus species with promising natural antibacterial agent to be used in clinical medicine. | ||||
| Keywords | ||||
| Aluminum Potassium Sulfate (alum); meropenem; amoxyclav; staphylococcus species; antimicrobial resistance | ||||
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