Attenuation Roles of Bioactive Compounds from Grapefruit against Silver Nanoparticles Induced Pulmonary Toxicity and Oxidative Stress
Younis, E., Aly, H., Ali, S. (2023). Attenuation Roles of Bioactive Compounds from Grapefruit against Silver Nanoparticles Induced Pulmonary Toxicity and Oxidative Stress. EKB Journal Management System, 66(13), 1719-1732. doi: 10.21608/ejchem.2023.223508.8270
Eman Younis; Hanan Farouk Aly; Sanaa Ahmed Ali. "Attenuation Roles of Bioactive Compounds from Grapefruit against Silver Nanoparticles Induced Pulmonary Toxicity and Oxidative Stress". EKB Journal Management System, 66, 13, 2023, 1719-1732. doi: 10.21608/ejchem.2023.223508.8270
Younis, E., Aly, H., Ali, S. (2023). 'Attenuation Roles of Bioactive Compounds from Grapefruit against Silver Nanoparticles Induced Pulmonary Toxicity and Oxidative Stress', EKB Journal Management System, 66(13), pp. 1719-1732. doi: 10.21608/ejchem.2023.223508.8270
Younis, E., Aly, H., Ali, S. Attenuation Roles of Bioactive Compounds from Grapefruit against Silver Nanoparticles Induced Pulmonary Toxicity and Oxidative Stress. EKB Journal Management System, 2023; 66(13): 1719-1732. doi: 10.21608/ejchem.2023.223508.8270

Attenuation Roles of Bioactive Compounds from Grapefruit against Silver Nanoparticles Induced Pulmonary Toxicity and Oxidative Stress

Egyptian Journal of Chemistry
Volume 66, Issue 13, December 2023, Page 1719-1732  XML PDF (854.02 K)
Document Type: Original Article
DOI: 10.21608/ejchem.2023.223508.8270
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Authors
Eman Younisorcid 1; Hanan Farouk Alyorcid 2; Sanaa Ahmed Ali email orcid 3
1National Research Centre ,Cairo, Egypt
2Deprtment of Therapeutic Chemistry , National Research Centre (NRC),El Behouth St. , P.O.12622. Dokki, Giza, Egypt.
3National Research Centre, Department of Therapeutic Chemistry- Egypt
Abstract
The therapeutic potential of methanolic extract, pectin, hesperidin, and naringin derived from Citrus paradisi peel (grapefruit) was investigated against the toxicity of silver nanoparticles (AgNPs). Mice received orally AgNPs of size 20 &100nm for four weeks then treated with methanolic extract, pectin, hesperidin, and naringin for three weeks. C. paradisi peel yielded methanolic extract (11.37%), pectin (30.88%), naringin (4.3%) and hesperidin (0.09%),the results showed a significant reduction in lung tissue ;Adenosine triphosphate ,Adenosine diphosphate and Adenosine monophosphate respectively (ATP, ADP, AMP), total adenylate (TA), inorganic phosphate (IP), phosphate potential (PP), and adenylate Energy Charge (AEC). Besides, obvious decrease in both vitamin E and C levels in both sizes of Ag–intoxicated, along with marked inhibition in superoxide dismutase (SOD) and catalase antioxidant enzyme activities. While oxidative stress markers; MDA was significantly elevated. More severe damage was detected with a smaller size of 20 nm than 100 nm AgNPs particle size compared to the control mice. Histopathological examination revealed inflammation and cellular degeneration caused by AgNPs after, treatment with the above compounds showing repair ease. C. paradisi derived by products including phenolic extract, pectin, hesperidin, and naringin that are handled unexpectedly as promising competitor remedial specialists against poisonousness induced by AgNPs in mice.
Keywords
Silver nanoparticles; ATP; Citrus paradisi; Phenolic compound; Pectin; Hesperidin; Naringin
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