Monkeypox: Insights into virus morphology, clinical manifestations, and mitigation strategies in developing nations
Khadka, R., Karki, K., Chaudhary, G., Pandey, J. (2023). Monkeypox: Insights into virus morphology, clinical manifestations, and mitigation strategies in developing nations. EKB Journal Management System, 7(4), 2081-2092. doi: 10.21608/nrmj.2023.313345
Ram Bahadur Khadka; Khimdhoj Karki; Gautam Prasad Chaudhary; Jitendra Pandey. "Monkeypox: Insights into virus morphology, clinical manifestations, and mitigation strategies in developing nations". EKB Journal Management System, 7, 4, 2023, 2081-2092. doi: 10.21608/nrmj.2023.313345
Khadka, R., Karki, K., Chaudhary, G., Pandey, J. (2023). 'Monkeypox: Insights into virus morphology, clinical manifestations, and mitigation strategies in developing nations', EKB Journal Management System, 7(4), pp. 2081-2092. doi: 10.21608/nrmj.2023.313345
Khadka, R., Karki, K., Chaudhary, G., Pandey, J. Monkeypox: Insights into virus morphology, clinical manifestations, and mitigation strategies in developing nations. EKB Journal Management System, 2023; 7(4): 2081-2092. doi: 10.21608/nrmj.2023.313345

Monkeypox: Insights into virus morphology, clinical manifestations, and mitigation strategies in developing nations

Novel Research in Microbiology Journal
Volume 7, Issue 4, July and August 2023, Page 2081-2092  XML PDF (305.13 K)
Document Type: Review Article
DOI: 10.21608/nrmj.2023.313345
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Authors
Ram Bahadur Khadka email orcid 1; Khimdhoj Karkiorcid 1; Gautam Prasad Chaudharyorcid 2; Jitendra Pandeyorcid 3
1Department of laboratory science, Crimson College of Technology, Affiliated with Pokhara University, Butwal-11, Devinagar, Rupandehi, Nepal
2Department of Pharmacy, Crimson College of Technology, Affiliated with Pokhara University, Butwal-11, Devinagar, Rupandehi, Nepal
3Department of Chemistry, University of Hawai’i at Manoa, 2545 McCarthy Mall, Honolulu, HI 96822, USA
Abstract
Monkeypox is an emerging zoonotic disease caused by the monkeypox virus (MPXV) and shares similarities with the other Orthopoxviruses. This review aimed to explore the morphology of MPXV, clinical manifestations, and mitigation strategies in the developing nations. Clinically, MPXV resembles smallpox. It has an unidentified natural host, despite it has been isolated from the rope squirrels and Sooty mangabeys. Transmission occurs through the respiratory excretions, saliva, contact with lesions, and potentially via the feces. The disease comprises a prodromal phase and subsequent skin rash. Originating in 1959 following a monkey outbreak in Copenhagen's research institute; the initial human case was documented in 1970 in the Democratic Republic of Congo. The virus subsequently dispersed globally; impacting several nations such as UK, USA, Israel, and Singapore. Thus, in addition to the healthcare infrastructure, combating monkeypox in the developing countries requires bolstering the disease surveillance, public awareness, diagnostic capabilities, and vaccination campaigns. Sustainable international collaboration and extensive scientific investigations are crucial for safeguarding the public health and preventing further spread of this viral disease.
Keywords
Monkeypox; Zoonotic disease; Orthopoxviruses; Clinical manifestations; Mitigation strategies
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