Study of (TLR-4) Gene Polymorphism (rs4986791) in Type 2 Diabetes and Diabetic Nephropathy in Egyptian Patients
Abd El-Hassib, D., Tolba, F., Ibrahim, M., Elzamly, S., abdelmotaleb, D. (2023). Study of (TLR-4) Gene Polymorphism (rs4986791) in Type 2 Diabetes and Diabetic Nephropathy in Egyptian Patients. EKB Journal Management System, 40(2), 495-504. doi: 10.21608/bmfj.2023.222168.1852
Dalia M. Abd El-Hassib; Fetnat Mahmoud Tolba; Mohamed E. Ibrahim; Sarah Abdelhakeem Elzamly; Dina saad abdelmotaleb. "Study of (TLR-4) Gene Polymorphism (rs4986791) in Type 2 Diabetes and Diabetic Nephropathy in Egyptian Patients". EKB Journal Management System, 40, 2, 2023, 495-504. doi: 10.21608/bmfj.2023.222168.1852
Abd El-Hassib, D., Tolba, F., Ibrahim, M., Elzamly, S., abdelmotaleb, D. (2023). 'Study of (TLR-4) Gene Polymorphism (rs4986791) in Type 2 Diabetes and Diabetic Nephropathy in Egyptian Patients', EKB Journal Management System, 40(2), pp. 495-504. doi: 10.21608/bmfj.2023.222168.1852
Abd El-Hassib, D., Tolba, F., Ibrahim, M., Elzamly, S., abdelmotaleb, D. Study of (TLR-4) Gene Polymorphism (rs4986791) in Type 2 Diabetes and Diabetic Nephropathy in Egyptian Patients. EKB Journal Management System, 2023; 40(2): 495-504. doi: 10.21608/bmfj.2023.222168.1852

Study of (TLR-4) Gene Polymorphism (rs4986791) in Type 2 Diabetes and Diabetic Nephropathy in Egyptian Patients

Benha Medical Journal
Article 17, Volume 40, Issue 2, September and October 2023, Page 495-504  XML PDF (720.25 K)
Document Type: Original Article
DOI: 10.21608/bmfj.2023.222168.1852
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Authors
Dalia M. Abd El-Hassib1; Fetnat Mahmoud Tolba2; Mohamed E. Ibrahim3; Sarah Abdelhakeem Elzamly email 4; Dina saad abdelmotaleborcid 5
1Clinical and Chemical Pathology, Faculty of Medicine, Benha University, Egypt.
2Clinical and Chemical Pathology Department, Faculty of Medicine, Benha University, Egypt.
3Internal Medicine, Faculty of Medicine, Benha University, Egypt.
4Clinical and Chemical Pathology, Faculty of Medicine, Benha university, Benha, Egypt
5Clinical and Chemical Pathology, Faculty of Medicine, Benha University, Benha, Egypt.
Abstract
Abstract:
Background:
A member of pattern recognition receptors is the toll-like receptor 4 (TLR-4). It is a highly conserved receptor that can identify compounds like damage- and pathogen-associated molecular patterns. As inflammation is considered to have a very important role in Type 2 diabetes (T2D) and toll-like receptors play a central role in inflammation through immune responses, TLR-4 has a universal role in the T2D mechanism. Excessive amounts of glucose and free fatty acids lead to enlarged expression of TLR-4 mRNA and proteins in cases with T2D.
Aim of the study:
To determine the role of TLR-4 gene polymorphism (rs4986791), threonine 399 isoleucine (Thr399Ile) in the pathogenesis of T2D and diabetic nephropathy (DN) Egyptian patients.
subjects and methods:
Sixty patients with T2D, thirty of them with DN and thirty without DN and twenty healthy controls had been genotyped for Thr399Ile polymorphisms of the TLR-4 gene by quantitative real-time PCR.
Results:
Toll-like receptor 4 polymorphism CT and TT genotypes and T allele found the relationship to T2D (P1). But there had been no significant relationship regarding TLR-4 gene polymorphism among patients with and without nephropathy (P=.674 and .296) for CT and TT genotypes.
Conclusion:
This study elucidated that the distinguished distribution of genotypes CT and TT of TLR-4 gene polymorphism (rs4986791) among T2D patients and healthy subjects is allied with an increased risk of T2D. But there had been no significant relationship with diabetic nephropathy in Egyptian populations.
Keywords
Type 2 Diabetes; Diabetic nephropathy; Toll-like receptor 4; rs4986791; polymorphism
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