Serum Interleukin-17 Level in Patients with Rheumatoid Arthritis and its Relation to Disease Activity
Atwa, S., Azab, M., Mohamed, M., El sheikh, M. (2020). Serum Interleukin-17 Level in Patients with Rheumatoid Arthritis and its Relation to Disease Activity. EKB Journal Management System, 26(1), 87-93. doi: 10.21608/zumj.2019.11577.1196
Shimaa Essam Atwa; Magda Mostafa Azab; Mervat Soliman Mohamed; mazen Mohamed El sheikh. "Serum Interleukin-17 Level in Patients with Rheumatoid Arthritis and its Relation to Disease Activity". EKB Journal Management System, 26, 1, 2020, 87-93. doi: 10.21608/zumj.2019.11577.1196
Atwa, S., Azab, M., Mohamed, M., El sheikh, M. (2020). 'Serum Interleukin-17 Level in Patients with Rheumatoid Arthritis and its Relation to Disease Activity', EKB Journal Management System, 26(1), pp. 87-93. doi: 10.21608/zumj.2019.11577.1196
Atwa, S., Azab, M., Mohamed, M., El sheikh, M. Serum Interleukin-17 Level in Patients with Rheumatoid Arthritis and its Relation to Disease Activity. EKB Journal Management System, 2020; 26(1): 87-93. doi: 10.21608/zumj.2019.11577.1196

Serum Interleukin-17 Level in Patients with Rheumatoid Arthritis and its Relation to Disease Activity

Zagazig University Medical Journal
Article 10, Volume 26, Issue 1, January and February 2020, Page 87-93  XML PDF (1.02 MB)
Document Type: Original Article
DOI: 10.21608/zumj.2019.11577.1196
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Authors
Shimaa Essam Atwa email 1; Magda Mostafa Azab2; Mervat Soliman Mohamed2; mazen Mohamed El sheikh3
1Medical Microbiology and Immunology Department, Faculty of Medicine - Zagazig University
2Professor of Medical Microbiology and Immunology, Faculty of Medicine - Zagazig University
3Professor of Rheumatology and Rehabilitation, Faculty of Medicine - Zagazig University
Abstract
Background: Rheumatoid arthritis (RA) is a disease of progressive inflammatory autoimmune nature with articular and systemic effects. Its definite cause is unknown, but environmental and genetic factors are contributory. Aim of the Work: The aim of this study was to estimate the serum level of IL-17 in cases with RA and investigate its relation with disease activity among Egyptian population. Subjects and Methods: This study included 20 RA cases and 20 healthy control subjects. All cases were subjected to full history taking, thorough clinical examination, laboratory investigations including erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), anti-cyclic-citrullinated peptide (anti-CCP) antibodies and rheumatoid factor (RF). Enzyme linked immunosorbent assay was used to measure serum IL-17 level. Disease activity score-28 (DAS-28) was assessed. Results: The mean disease duration of the cases was 5.95±2.52 years (2–10years). DAS-28 ranged between 2.4 and 6.1 with a mean of 3.87±1.32. Serum IL-17 level was higher in the RA group (226.6±215.6 pg/ml) than the control group (48.17±54.9pg/ml) with p-value of 98.2 pg/ml had sensitivity and specificity of 81.2% and 75%, respectively. Conclusion: Serum IL-17 level was significantly increased in cases with RA compared to healthy controls. Its significant correlation with DAS-28 suggested that serum IL-17 level could be an important marker of disease activity in RA.
Keywords
Serum Interleukin-17; Rheumatoid Arthritis; disease activity
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