Vitamin D mitigates hippocampus apoptosis induced by diabetes | ||||
| SVU-International Journal of Medical Sciences | ||||
| Article 57, Volume 6, Issue 2, July 2023, Page 586-596 PDF (699.02 K) | ||||
| Document Type: Original research articles | ||||
| DOI: 10.21608/svuijm.2023.223892.1623 | ||||
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| Authors | ||||
Omyma Galal Ahmed1; Khaled Ahmed Abdel-Sater Eliwa2; Rana Toghan3; Sabah Ahmed Mohamed Fadel4; Sahar Marei Zaki  3
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| 1Physiology Department , Faculty of Medicine,Assiut University,Assiut, Egypt. | ||||
| 2Physiology Department ,Faculty of Medicine, Al-Azhar University (Assiut Branch), Assiut, Egypt. | ||||
| 3Physiology Department ,Faculty of Medicine,South Valley University,Qena, Egypt. | ||||
| 4Pathology Department ,Faculty of Medicine, Assiut University,Assiut, Egypt. | ||||
| Abstract | ||||
| Background: Diabetes mellitus (DM) is a chronic progressive metabolic illness and that is greatly associated with an increased risk of developing cognitive deficits. Numerous previous studies have indicated that vitamin D has neuroprotective effects. However, the impact of vitamin D on type 2 diabetes mellitus (T2DM)-associated hippocampal damage in the brain and its protective mechanism remains unclear. Objectives: We investigated the effect of vitamin D supplementation on diabetes-related apoptotic changes in the hippocampus of diabetic rats. Materials and methods: Our study is an experimental randomized control trial conducted between November 2020 to March 2021in the Physiology Department, Faculty of Medicine, South valley university. We constructed a T2DM rat model on 24 Male albino Sprague Dowely rats; diabetes was induced by a high- fat diet and a single low dose of streptozotocin (STZ) (30mg/kg). Animals were divided into four groups; Normal control, Control receiving vitamin D (VD), Diabetic control, and Diabetic receiving vitamin D group. Results: Compared with the control, results showed decreased spontaneous alternation T maze cognitive test, declined neural survival and increased immunohistochemistry expression of Synaptophysin in the hippocampus in diabetic rats. Vitamin D supplementation for six weeks can ameliorate diabetes-associated cognitive impairments by increasing neural cell survival and reducing neural apoptosis in the hippocampus. Conclusion: The resulting data have the potential to provide vitamin D as a new type of adjuvant agent for anti-diabetic lines of treatment. | ||||
| Keywords | ||||
| T2DM; Apoptosis; Vitamin D; Synaptophysin; Cognition | ||||
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