The prophylactic and therapeutic effects of the phytochemical combination breast safeguard on Ehrlich cell progression | ||||
| Journal of Environmental Sciences. Mansoura University | ||||
| Volume 50, Issue 4, December 2021, Page 98-103 PDF (364.53 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/joese.2021.314030 | ||||
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| Authors | ||||
| Heba Alwasify* 1; Yousra M El-Far2; Mohamed E. Abdraboh1 | ||||
| 1Zoology Department, Faculty of Science, Mansoura University, Egypt | ||||
| 2Biochemistry department, Faculty of Pharmacy, Mansoura University. Egypt | ||||
| Abstract | ||||
| 2 million new cases in 2019. Phytochemicals have been used in traditional medicine for centuries, however, they recently gained attention in cancer research due to their potent antioxidant, anti-inflammatory, and immunomodulatory effects. This study aimed to elucidate the prophylactic and/or therapeutic effect of a phytochemical combination “Breast safeguard” on mammary adenocarcinoma in vivo model of Ehrlich cells. Thirty mice were randomized into three groups of Ehrlich group, the Prophylactic group, and the BSG-treated group. A marked enhancement in the mice survival rate and a significant reduction in tumor size was recognized after two weeks of treatment. And TNF-α, and Bax/Bcl2 ratio markers for cancer prognosis and apoptosis, the results showed a significant decrease in tumor volume in the protective group than in the treated one. This phytochemicals combination showed a potent anticancer characteristic by inhibiting Ehrlich tumor proliferation and induction of cell apoptosis indicating its possible use as a promising prophylactic drug in prospective studies | ||||
| Keywords | ||||
| Phytochemicals; Breast safeguard; Ehrlich; Adenocarcinoma; Apoptosis | ||||
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