Biochemical Study on antioxidant after High Effort | ||||
| Benha Veterinary Medical Journal | ||||
| Article 40, Volume 30, Issue 1, March 2016, Page 358-367 PDF (292.13 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bvmj.2016.31406 | ||||
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| Authors | ||||
| Abdel-Maksoud A. Hussien1; Mahmoud Rabie Ahmed1; Mohammed A. Hussein2; Naglaa Abd El-Khalik Gobba3 | ||||
| 1Department of Biochemistry, Faculty of Veterinary Medicine, Benha University, 13736 Moshtohor, Qalioubeya, Egypt | ||||
| 2Biochemistry Department, Faculty of Pharmacy, October 6th University, October 6th city, Egypt | ||||
| 3Department of Pharmacology, Faculty of Pharmacy, Misr University for Science and Technology (MUST), October 6th City, Egypt | ||||
| Abstract | ||||
| The present study was designed to evaluate hepatoprotective effects of Cranberry extract (75 and 150mg/kg.b.w) against Diclofenac sodium induced liver toxicity in rats. Oral administration of Diclofenac sodium (150mg/kg.b.w.) led to significant increase in plasma Transaminases (L-Alanine and L-Aspartate), Lactate dehydrogenase (LDH), Alkaline phosphatase (ALP), Tumor Nicroses Factor-Alfa (TNF-α), Nitric oxide (NO) and TBARS as well as plasma, Triacylglycerol, Total Cholesterol, and LDLCholesterol. Also, treatment of rats with Diclofenac sodium led to significant decrease in liver GSH, Protein Thiols (Pr-SHs), Superoxide Dismutase (SOD), Catalase (CAT) as well as plasma HDL. The obtained result revealed that cranberry extract (75 and 150mg/kg.b.w.) prevent liver tissue damage through increasing of GSH, SOD and CAT activities and decrease significantly TBARs level. These results suggest that, cranberry may be effective in enhances the protection of heart toxicity by its radical scavenging effect and antioxidant activity | ||||
| Keywords | ||||
| diclofenac sodium; liver toxicity; cranberry; Antioxidant enzymes; Lipid profile; GSH | ||||
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