Tumor necrosis factor-related apoptosis- inducing ligand polymorphism.
Mohammed, S., Soliman, T., Mahmoud, A., Sedeek, O. (2023). Tumor necrosis factor-related apoptosis- inducing ligand polymorphism.. EKB Journal Management System, 27(3), 53-56. doi: 10.21608/smj.2023.226963.1404
Shaimaa Abd El Kareem Mohammed; Tamer Mohammed Soliman; Ahmed Sedky Mahmoud; Osama Bakr Sedeek. "Tumor necrosis factor-related apoptosis- inducing ligand polymorphism.". EKB Journal Management System, 27, 3, 2023, 53-56. doi: 10.21608/smj.2023.226963.1404
Mohammed, S., Soliman, T., Mahmoud, A., Sedeek, O. (2023). 'Tumor necrosis factor-related apoptosis- inducing ligand polymorphism.', EKB Journal Management System, 27(3), pp. 53-56. doi: 10.21608/smj.2023.226963.1404
Mohammed, S., Soliman, T., Mahmoud, A., Sedeek, O. Tumor necrosis factor-related apoptosis- inducing ligand polymorphism.. EKB Journal Management System, 2023; 27(3): 53-56. doi: 10.21608/smj.2023.226963.1404

Tumor necrosis factor-related apoptosis- inducing ligand polymorphism.

Sohag Medical Journal
Volume 27, Issue 3, 2023, Page 53-56  XML PDF (1018.95 K)
Document Type: Review Article
DOI: 10.21608/smj.2023.226963.1404
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Authors
Shaimaa Abd El Kareem Mohammed email 1; Tamer Mohammed Soliman2; Ahmed Sedky Mahmoud3; Osama Bakr Sedeek4
1Clinical and chemical pathology, Faculty of Medicine, Sohag University
2Department:Clinical and chemical pathology, Faculty of Medicine, Sohag university
3Department: Clinical and chemical pathology, Faculty of Medicine , Sohag university
4Department: Clinical and chemical pathology, Faculty of Medicine, Assuit University
Abstract
Abstract:

TNF superfamily member (TRAIL) is a type II transmembrane protein and is responsible for initiating apoptosis. Macrophages, natural killer (NK), dendritic cells (DCs) and T cells all have TRAIL on their outer surfaces. Like other cytokines, the mature released protein lacks the signal sequence that is present in its pro-form. TRAIL can either be secreted as a dissolved protein or hydrophobic amino acids can attach it to the membrane. Both kinds can act as trimesters and initiate cell death. TRAIL promotes cell death by attaching to and activating trimeric death receptor. TRAIL is able to connect to five different receptors

Keywords: Secretion and exoression, Function of TRAIL, Mechanism of TRAIL Signaling Pathway, DISC, FADD, TRAIL Signaling Inhibition and TRAIL protect against diabetes.

Abbreviations: TRAIL: Tumor necrosis factor-related apoptosis-inducing ligand, NK: Natural killer, DC: dendritic cells, IFN: interferon, DISC: death inducing signaling complex, FADD : Fas associated death domain .
Keywords
Function of TRAIL; DISC; FADD
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