correlation of serum Galectin-3 level with disease activity in Rheumatoid Arthritis patients.
Eltoukhy, M., Elsayed, E., Esawy, M., Ebaid, A. (2024). correlation of serum Galectin-3 level with disease activity in Rheumatoid Arthritis patients.. EKB Journal Management System, 30(1.3), 172-179. doi: 10.21608/zumj.2023.226886.2837
Mirvat Abdelhamid Eltoukhy; Esraa Mohsen Elsayed; Marwa Mohammed Esawy; Amany Mohammed Ebaid. "correlation of serum Galectin-3 level with disease activity in Rheumatoid Arthritis patients.". EKB Journal Management System, 30, 1.3, 2024, 172-179. doi: 10.21608/zumj.2023.226886.2837
Eltoukhy, M., Elsayed, E., Esawy, M., Ebaid, A. (2024). 'correlation of serum Galectin-3 level with disease activity in Rheumatoid Arthritis patients.', EKB Journal Management System, 30(1.3), pp. 172-179. doi: 10.21608/zumj.2023.226886.2837
Eltoukhy, M., Elsayed, E., Esawy, M., Ebaid, A. correlation of serum Galectin-3 level with disease activity in Rheumatoid Arthritis patients.. EKB Journal Management System, 2024; 30(1.3): 172-179. doi: 10.21608/zumj.2023.226886.2837

correlation of serum Galectin-3 level with disease activity in Rheumatoid Arthritis patients.

Zagazig University Medical Journal
Article 21, Volume 30, Issue 1.3, March and April 2024, Page 172-179  XML PDF (1.05 MB)
Document Type: Original Article
DOI: 10.21608/zumj.2023.226886.2837
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Authors
Mirvat Abdelhamid Eltoukhy1; Esraa Mohsen Elsayed email 2; Marwa Mohammed Esawyorcid 3; Amany Mohammed Ebaid1
1Rheumatology and rehabilitation department, faculty of medicine, Zagazig university, Zagazig, Egypt
2Rheumatology and rehabilitation department, faculty of medicine, Zagazig unizersity, Zagazig, Egypt
3clinical pathology department, faculty of medicine, zagazig university, Zagazig, Egypt
Abstract
ABSTRACT

Background: Rheumatoid arthritis (RA) is a multifactorial autoimmune illness that causes symmetric polyarthritis and can result in deformities in addition to several extra articular manifestations. Galectin-3 is a protein involved in modulating inflammation and apoptosis. The objective of this work is to measure the serum level of Galectin-3 in RA patients and to assess its correlation with disease activity.

Subjects and Methods: A case control study was carried on 66 subjects, 33 RA patients ( 28 females and 5 males), and 33 healthy subjects, taken as control (23 females and 10 males). Disease Activity score (DAS28) was estimated for RA patients. Blood samples from patients and controls were tested for Galectin-3.

Results: Serum Galectin-3 levels were substantially greater (P<0.001) in RA patients than in controls as it ranged between (2.3-33.6 ng/ml vs 5.21-9.67 ng/ml P<0.001). Serum Galectin-3 correlated with DAS28 (r=0.62, p=<0.001), CRP (r=0.35, p=0.04) also with ESR (r=0.36, p=0.04). Galectin-3 showed a sensitivity of 96.97% and a specificity of 84.85% at a cutoff of 6.95 ng/ml to discriminate RA from controls.

Conclusion: Serum Galectin-3 levels were higher in RA patients than in controls and correlated with disease activity So, Galectin-3 can be used as a biomarker for RA disease activity.

Keywords: Rheumatoid arthritis, Disease activity, serum Galectin-3.
Keywords
Rheumatoid arthritis; Disease activity; serum Galectin-3
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