The Significance of Expression of MUC 4 and IMP-3 in Benign Prostatic Hyperplasia, High Grade Prostatic Intraepithelial Neoplasia and Prostatic Adenocarcinoma(immunohistochemical study)
Elshawarby, Z., El Attar, K., shalan, N. (2023). The Significance of Expression of MUC 4 and IMP-3 in Benign Prostatic Hyperplasia, High Grade Prostatic Intraepithelial Neoplasia and Prostatic Adenocarcinoma(immunohistochemical study). EKB Journal Management System, 40(2), 462-473. doi: 10.21608/bmfj.2023.203221.1795
Zeinab Ibrahim Elshawarby; kareem Ali El Attar; naglaa hamed shalan. "The Significance of Expression of MUC 4 and IMP-3 in Benign Prostatic Hyperplasia, High Grade Prostatic Intraepithelial Neoplasia and Prostatic Adenocarcinoma(immunohistochemical study)". EKB Journal Management System, 40, 2, 2023, 462-473. doi: 10.21608/bmfj.2023.203221.1795
Elshawarby, Z., El Attar, K., shalan, N. (2023). 'The Significance of Expression of MUC 4 and IMP-3 in Benign Prostatic Hyperplasia, High Grade Prostatic Intraepithelial Neoplasia and Prostatic Adenocarcinoma(immunohistochemical study)', EKB Journal Management System, 40(2), pp. 462-473. doi: 10.21608/bmfj.2023.203221.1795
Elshawarby, Z., El Attar, K., shalan, N. The Significance of Expression of MUC 4 and IMP-3 in Benign Prostatic Hyperplasia, High Grade Prostatic Intraepithelial Neoplasia and Prostatic Adenocarcinoma(immunohistochemical study). EKB Journal Management System, 2023; 40(2): 462-473. doi: 10.21608/bmfj.2023.203221.1795

The Significance of Expression of MUC 4 and IMP-3 in Benign Prostatic Hyperplasia, High Grade Prostatic Intraepithelial Neoplasia and Prostatic Adenocarcinoma(immunohistochemical study)

Benha Medical Journal
Article 14, Volume 40, Issue 2, September and October 2023, Page 462-473  XML PDF (778.72 K)
Document Type: Original Article
DOI: 10.21608/bmfj.2023.203221.1795
View on SCiNiTO View on SCiNiTO
Authors
Zeinab Ibrahim Elshawarby1; kareem Ali El Attar2; naglaa hamed shalan email 3
1pathology,faculty of medicie,Benha university,Egypt
2urology department,benha faculty of medicine,benha university,benha, Egypt
3pathology.faculty of medicine,Benha university,Benha
Abstract
Background : Prostate cancer is one of the most frequent malignancy worldwide . Mucin 4(MUC4) is a transmembrane mucin that is contributed in cell signalling events that guide the proliferation of cells. Insulin-like growth factor 2 (IGF2) messenger RNA binding protein 3 (IMP3) has been linked to tumorgenesis and progression of many cancers.
Aim: This study aimed to evaluate MUC4 and IMP-3 expression in different prostatic lesions and to relate the results with clinicopathological data.
Material & method:
This retrospective study examined 40 cases including10 cases of benign prostatic hyperplasia (BPH), 6 cases of high-grade prostatic intraepithelial neoplasia (HGPIN) and 24 cases of prostatic adenocarcinoma (PCa) . MUC 4 and IMP-3 were used for the immunohistochemistry.
Results: MUC4 was detected in (100%) of BPH & HGPIN cases and (16.6%) of prostatic carcinoma.IMP3 expressed in (100%) of prostatic cancer cases and expressed in(10%) &(16.7%) of &HGPIN respectively. A significant statistical correlations between IMP3expression and stage, Gleason’s grade ,pre OP serum PSA level>10ng/ml, capsular and perineural invasion(P
Keywords
MUC4; IMP3.BPH; Prostatic adenocarcinoma
Statistics
Article View: 182
PDF Download: 338