TRAIL Single Nucleotide Polymorphism in Type 2 Egyptian Diabetic Patients | ||||
| Sohag Medical Journal | ||||
| Volume 27, Issue 3, 2023, Page 47-52 PDF (853.87 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/smj.2023.226952.1402 | ||||
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| Authors | ||||
Shaimaa Abd El Kareem Mohammed  1; Tamer Mohammed Soliman2; Ahmed Sedky Mahmoud3; Osama Bakr Sedeek4
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| 1Clinical and chemical pathology, Faculty of Medicine, Sohag University | ||||
| 2Department:Clinical and chemical pathology, Faculty of Medicine, Sohag university | ||||
| 3Department: Clinical and chemical pathology, Faculty of Medicine , Sohag university | ||||
| 4Department: Clinical and chemical pathology, Faculty of Medicine, Assuit University | ||||
| Abstract | ||||
| Abstract Objective: The research attempted to assess the susceptibility of TRAIL polymorphism (rs1131580) in T2DM and its relationship with metabolic parameters in T2DM. Patients and Methods: This study was performed on 80 subjects, 60 patients with type 2 diabetes mellitus and age & sex matched 20 healthy volunteers as controls, The patients had complete clinical examination and detailed history (duration of diabetes, family history of diabetes and presence of complications) collection, and detection of TRAIL single nucleotide polymorphism rs1131580 by PCR-RFLP standing for polymerase chain reaction-restriction fragment length polymorphism.. Results: TRAIL SNP rs1131580 mutation was greatly more common in the group of diabetics when compared to the control group. Conclusion: A homozygous variant allele (CC) genotype of the TRAIL SNP rs1131580 carries a 1.5-fold risk of DM. Also, having the C allele elevated the risk of T2DM by 1.7 times. Keywords: Tumor necrosis factor-related apoptosis-inducing ligand, PCR-RFLP, Type 2 diabetes mellitus. | ||||
| Keywords | ||||
| Keywords: Tumor necrosis factor-related apoptosis-inducing ligand; PCR-RFLP; T2DM | ||||
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