Treatment of Helicobacter pylori in the Arab world: a systematic review and network meta-analysis
Afify, S., Abdel-Gawad, M., Bahbah, E., Zaghloul, M., abu-Elfatth, A., Alzamzamy, A., Nagui, G., Elwazzan, D., Abdeen, N., Tharwat, M., Elbahr, O., Charif, I., Aboufarrag, G., Elbadry, M., Omran, D., Abd-Elsalam, S., Ali-Eldin, Z., Makhlouf, N., Alboraie, M. (2023). Treatment of Helicobacter pylori in the Arab world: a systematic review and network meta-analysis. EKB Journal Management System, 1(1), -. doi: 10.21608/gg.2023.203591.1010
Shimaa Afify; Muhammad Abdel-Gawad; Eshak I. Bahbah; Mariam Zaghloul; Ahmed abu-Elfatth; Ahmed Alzamzamy; Gina Gamal Nagui; Doaa Elwazzan; Nermeen Abdeen; Mina Tharwat; Osama Elbahr; Iliass Charif; Galal Aboufarrag; Mohamed Elbadry; Dalia Omran; Sherif Abd-Elsalam; Zainab Ali-Eldin; Nahed A. Makhlouf; Mohamed Alboraie. "Treatment of Helicobacter pylori in the Arab world: a systematic review and network meta-analysis". EKB Journal Management System, 1, 1, 2023, -. doi: 10.21608/gg.2023.203591.1010
Afify, S., Abdel-Gawad, M., Bahbah, E., Zaghloul, M., abu-Elfatth, A., Alzamzamy, A., Nagui, G., Elwazzan, D., Abdeen, N., Tharwat, M., Elbahr, O., Charif, I., Aboufarrag, G., Elbadry, M., Omran, D., Abd-Elsalam, S., Ali-Eldin, Z., Makhlouf, N., Alboraie, M. (2023). 'Treatment of Helicobacter pylori in the Arab world: a systematic review and network meta-analysis', EKB Journal Management System, 1(1), pp. -. doi: 10.21608/gg.2023.203591.1010
Afify, S., Abdel-Gawad, M., Bahbah, E., Zaghloul, M., abu-Elfatth, A., Alzamzamy, A., Nagui, G., Elwazzan, D., Abdeen, N., Tharwat, M., Elbahr, O., Charif, I., Aboufarrag, G., Elbadry, M., Omran, D., Abd-Elsalam, S., Ali-Eldin, Z., Makhlouf, N., Alboraie, M. Treatment of Helicobacter pylori in the Arab world: a systematic review and network meta-analysis. EKB Journal Management System, 2023; 1(1): -. doi: 10.21608/gg.2023.203591.1010

Treatment of Helicobacter pylori in the Arab world: a systematic review and network meta-analysis

Global Gastroenterology
Volume 1, Issue 1, August 2023  XML PDF (940.76 K)
Document Type: Meta-analyses and research proposals which bring new innovations to the field of gastroenterology.
DOI: 10.21608/gg.2023.203591.1010
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Authors
Shimaa Afifyorcid 1; Muhammad Abdel-Gawadorcid 2; Eshak I. Bahbah3; Mariam Zaghloulorcid 4; Ahmed abu-Elfatthorcid 5; Ahmed Alzamzamyorcid 6; Gina Gamal Naguiorcid 7; Doaa Elwazzanorcid 8; Nermeen Abdeenorcid 9; Mina Tharwatorcid 10; Osama Elbahrorcid 11; Iliass Charif12; Galal Aboufarragorcid 13; Mohamed Elbadryorcid 14; Dalia Omran15; Sherif Abd-Elsalamorcid 16; Zainab Ali-Eldinorcid 7; Nahed A. Makhlouforcid 5; Mohamed Alboraieorcid 17
1Gastroenterology department, National Hepatology and Tropical Medicine Research Institute, Cairo, Egypt.
2Hepatology, Gastroenterology, and Infectious Diseases Department, Al-Azhar University, Assiut, Egypt.
3Faculty of Medicine, Al-Azhar University, Damietta, Egypt.
4Gastroenterology and Infectious Diseases department, Faculty of Medicine, Kafrelsheikh University, Kafrelsheikh, Egypt
5Tropical Medicine and Gastroenterology Department, Assuit University, Assuit Egypt.
6Department of Gastroenterology and Heptology, Maadi Armed Forces Medical Complex, Military Medical Academy,
7Department of internal medicine, Ain shams university, Cairo, Egypt
8Tropical Medicine Department, Alexandria Faculty of Medicine, Alexandria, Egypt
9Alexandria UniversityTropical Medicine Department, Alexandria Faculty of Medicine, Alexandria, Egypt
10Tropical medicine and Gastroenterology, Aswan University, Aswan, Egypt
11Hepatology and gastroenterology department National liver Institute Menofia university
12Department of hepatology and gastroenterology Al Farabi Hospital. Oujda. Morocco
13Hepatology, gastroenterology and infectious diseases Department, Al-Azhar University, Cairo, Egypt.
14Endemic Medicine Department, Faculty of Medicine, Helwan University, Cairo, Egypt.
15Department of Endemic Medicine and Hepatology, Faculty of Medicine, Cairo University, Cairo, Egypt
16Tropical Medicine and Infectious diseases Department, Tanta University, Tanta, Egypt
17Department of internal medicine, Al-Azhar University, Cairo 11884, Egypt.
Abstract
Purpose: We conducted a systematic review and network meta-analysis (NMA) to estimate the efficacy of Helicobacter pylori (H. pylori) treatment strategies in Arab countries.
Methods: We searched electronic databases from inception to July 18, 2020, using boolean operators. Search terms were (Helicobacter pylori R H. pylori OR pylori OR helicobacter). The risk of bias was assessed using Cochrane risk of bias tool. Retrieved articles were screened, and relevant data were extracted. We used R programming software to analyze extracted data.
Results: Fifty-four articles (n= 7829 patients) were included in the NMA. Pooled analysis demonstrated that adjuvant therapy (standard triple or sequential therapy plus another adjuvant drug) was the best treatment with higher odds of eradication rate [OR= 6.42, 95% CI (1.37: 30.05), P-score= 0.21]. In naïve population, quinolones-based therapy (QBT) and sequential therapy (SQT) were associated with higher eradication rates than other regimens [OR= 1.94, 95% CI (1.19: 3.16), P score=0.19] and [OR= 1.66, 95% CI (1.10: 2.50), P score=0.33]. In experienced population, all medication showed a non-significant difference in eradication rates when compared to triple therapy (TT); QBT (OR= 1.86, 95% CI, [0.15, 22.88], p=0.44) and SQT (OR= 1.49, 95% CI, [0.13, 17.59], p=0.52).
Conclusion: Our findings suggested that QBT and SQT therapies were the most effective regimens for eradicating H. pylori in naïve patients in the Arab countries. In experienced patients, all medication showed a non-significant difference in eradication rates.
Keywords
Eradication; Anti-Bacterial Agents; Quinolones, bismuth, resistance
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