Value of Anti-Müllerian Hormone in Diagnosis and Management of Children with Disorders of Sex Development | ||||
| Zagazig University Medical Journal | ||||
| Article 14, Volume 26, Issue 1, January and February 2020, Page 114-122 PDF (761.59 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/zumj.2019.11117.1163 | ||||
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| Authors | ||||
Ibrahim Shawky Ibrahim  1; Hossam Mostafa Kamal2; Ashgan Abd Allah Al-Gobashy3; Ebtehag Helmy Hassan4
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| 1Department of pediatrics, zagazig university | ||||
| 2pediatrics department, faculty of medicine, zagazig university | ||||
| 3Department of Pediatrics, Faculty of Medicine, Zagazig University, Egypt | ||||
| 4Department of clinical pathology, Faculty of Medicine, Zagazig University, Egypt | ||||
| Abstract | ||||
| Aim: to investigate the serum levels of AMH in children with disorders of sex development and its correlation with other diagnostic investigations to assess the ability of AMH to predict the presence and function of testicular tissue. Subjects& Methods: The study was carried out at the pediatric, pediatric surgery and clinical pathology departments at Zagazig University Hospitals (ZUH) during the period from February 2018 to December 2018. The study was performed on 40 infants and children below the age of ten years. They were divided into two groups, control and DSD groups, each group contained 20 participants. Children were subjected to full history taking, precise clinical examination, and investigations that included ultrasonography, karyotyping and biopsies. In addition, serum AMH, testosterone and dihydrotestosterone (DHT). Statistical analysis using suitable significance tests was performed. Results: Specificity and sensitivity of testosterone and DHT in detection of testicular activity were 100% for both while they were 91.7% and 100% respectively for AMH in 46,XY DSD. Conclusion: Serum testosterone and DHT had a better diagnostic role in 46.XY DSD than AMH while in 46,XX DSD, AMH is better. | ||||
| Keywords | ||||
| AMH; DSD; testosterone; dihydrotestosterone | ||||
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