Effect of ginger, garlic, and pomegranate extracts on biochemical and antioxidants parameters in Cryptosporidium parvum infected Albino mice
El-Shewehy, D., Elshobaky, G., Ismail, A., Hassan, S., Ramez, A. (2023). Effect of ginger, garlic, and pomegranate extracts on biochemical and antioxidants parameters in Cryptosporidium parvum infected Albino mice. EKB Journal Management System, 52(3), 106-114. doi: 10.21608/joese.2023.211040.1024
Dina El-Shewehy; Gehad Elshobaky; Amira Ismail; Shimaa Hassan; Amany Ramez. "Effect of ginger, garlic, and pomegranate extracts on biochemical and antioxidants parameters in Cryptosporidium parvum infected Albino mice". EKB Journal Management System, 52, 3, 2023, 106-114. doi: 10.21608/joese.2023.211040.1024
El-Shewehy, D., Elshobaky, G., Ismail, A., Hassan, S., Ramez, A. (2023). 'Effect of ginger, garlic, and pomegranate extracts on biochemical and antioxidants parameters in Cryptosporidium parvum infected Albino mice', EKB Journal Management System, 52(3), pp. 106-114. doi: 10.21608/joese.2023.211040.1024
El-Shewehy, D., Elshobaky, G., Ismail, A., Hassan, S., Ramez, A. Effect of ginger, garlic, and pomegranate extracts on biochemical and antioxidants parameters in Cryptosporidium parvum infected Albino mice. EKB Journal Management System, 2023; 52(3): 106-114. doi: 10.21608/joese.2023.211040.1024

Effect of ginger, garlic, and pomegranate extracts on biochemical and antioxidants parameters in Cryptosporidium parvum infected Albino mice

Journal of Environmental Sciences. Mansoura University
Volume 52, Issue 3, September 2023, Page 106-114  XML PDF (393.81 K)
Document Type: Original Article
DOI: 10.21608/joese.2023.211040.1024
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Authors
Dina El-Shewehy email orcid 1; Gehad Elshobaky2; Amira Ismail3; Shimaa Hassan4; Amany Ramez1
1Zoology Department, Faculty of Science, Mansoura University
2Department of Clinical Pathology, Faculty of Veterinary Medicine, Mansoura University
3Department of Parasitology, Faculty of Medicine, Mansoura University
4Zoology Department, Faculty of Science, Zagazig University
Abstract
Humans frequently contract the diarrheal disease known as cryptosporidiosis, which is brought on by the protozoan parasite Cryptosporidium. The current study looked at how pomegranate (Punica granatum) peel extracts, garlic (Allium sativum), and ginger (Zingiber officinale) affected the biochemical and antioxidant parameters of a mouse model of experimental cryptosporidiosis.

82 mice were allocated into 6 groups; Control group, Infected non-treated group (experimentally infected by 104 C. oocysts/mouse), Ginger, garlic, and pomegranate groups experimentally infected with C. parvum and treated with the plants’ extracts, as compared to the reference drug, metronidazole (MTZ).We observed that all therapies promoted liver function by reducing serum levels of the alanine aminotransferase (ALT) and aspartate aminotransferase (AST) enzymes and raising levels of total protein, albumin, and globulin. Furthermore, the levels of serum malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), and total antioxidant capacity (TAC) were likewise restored to nearly their normal values in the treated groups. Garlic extract was noticed to have a noteworthy impact on the infected mice than the other treatments and ameliorated health benefits, performing a natural efficient therapeutic alternative, without drug resistance and with the fewest side effects possible for treating cryptosporidiosis
Keywords
C. parvum; Antioxidant biomarkers, Biochemical parameters
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