ADDING L-CARNITINE AND VITAMIN D TO LETROZOLE IN OVULATION INDUCTION IN PCOS PATIENTS | ||||
ALEXMED ePosters | ||||
Article 1, Volume 5, Issue 3, September 2023, Page 44-45 | ||||
Document Type: Preliminary preprint short reports of original research | ||||
DOI: 10.21608/alexpo.2023.233580.1682 | ||||
View on SCiNiTO | ||||
Authors | ||||
Samir Elsaid1; Tarek Mokhtar Hussein Toppozada2; Hisham Adel Hanafi El Fazary3; Asmaa Sayed Tohamy Mohamed Emam 3 | ||||
1Department of Obstetrics and Gynecology, Faculty of Medicine, Alexandria University, Egypt | ||||
2Department of Obstetrics and Gynaecology, Faculty of Medicine, Alexandria University | ||||
3Department of Obstetrics and Gynecology, Faculty of Medicine, Alexandria University | ||||
Abstract | ||||
INTRODUCTION Carnitine has been also used in the treatment of insulin resistance. Vitamin D has a physiologic role in reproduction including ovarian follicular development and luteinization through changing anti-müllerian hormone (AMH) signalling, follicle-stimulating hormone sensitivity and progesterone production. OBJECTIVE Investigation of the efficacy of combining l-carnitine with vitamin D added to letrozole in comparison to letrozole only for ovulation induction in infertile women with polycystic-ovarian-syndrome (PCOS) as regards the endometrial thickness, ovulation rate, pregnancy rate, rate of mono-follicular development and time to conception. METHODS During this study, 94 infertile women were enrolled, after consenting each of them and divided into two groups; Regarding first group participants, they received ovulation induction plus oral-carnitine (3g) supplementation combined with 800 IU vitamin D per day for two cycles or till the conception combined with letrozole, while the second group participants received letrozole as 5mg once daily for five days (from day 3 to 7) after spontaneous or progesterone induced bleeding and increased to 7.5mg in the following cycle if ovulation did not occur. | ||||
Keywords | ||||
L-CARNITINE; VITAMIN D; PCOS | ||||
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