Relationship Between Platelet Indices and Severity of COVID-19 Infection. | ||||
| Benha Medical Journal | ||||
| Articles in Press, Accepted Manuscript, Available Online from 03 September 2023 PDF (399.39 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bmfj.2023.221152.1848 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Mahmoud Rizk; Mohamed El Assal; Fawzy Megahed Khalil; El Mokhtar Ould El Hamed Ould Ahmed  ; Mohamed Abd Ellatif Afifi
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| Department of Internal Medicine, Faculty of Medicine, Benha University, Egypt | ||||
| Abstract | ||||
| Abstract: Coronavirus disease of 2019 (COVID-19) has resulted in millions of cases worldwide. As the pandemic has progressed, the understanding of this disease has evolved. Both arterial and venous thrombosis are primarily caused by platelets, and platelet-virus interactions increase the risk of thrombosis by encouraging pro-inflammatory and procoagulant states during viral infection. Aim: To investigate the relationship between platelet indices such as platelet count (PLT), mean platelet volume (MPV), platelet distribution width (PDW), plateletcrit (PCT), platelet large cell count (PLCC), and platelet large cell ratio (PLCR) and severity of illness in patients with COVID-19. Methods: A case-control study included 50 patients with COVID-19 infection and 50 healthy individuals (control group), patients were selected from outpatient clinic, internal medicine department, intermediate, and intensive care units at Benha University Hospital, Egypt. Platelet indices were recorded from both groups. Results: COVID-19 cases were significantly associated with higher MPV and PLCR, significantly lower PLT, PCT, PDW, and PLCC when compared to control group. Severity showed significant positive correlations with MPV, PLCR and significant negative correlations with PLT and PCT. While no significant correlations were found between severity with PDW or PLCC. Lower PLT, higher MPV and PLCR, were considered unfavourable risk predictors of COVID-19 severity. Lower PLT, higher MPV and PLCR were considered unfavourable risk predictors of COVID-19 mortality. Conclusion: Platelet indices like PLT, PCT, MPV, PDW, PLCC, and PLCR could be used as efficient diagnostic and prognostic biomarkers for COVID-19. | ||||
| Keywords | ||||
| COVID-19; Platelet Indices; Platelet Count; Severity | ||||
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