New predictive tools for liver fibrosis among non-apparently contaminated heavy metal workers
Abdel-Hamid, N., Abdel Hamid, M., Mohamed, A., Mohamed, A. (2023). New predictive tools for liver fibrosis among non-apparently contaminated heavy metal workers. EKB Journal Management System, 5(3), 195-207. doi: 10.21608/jmals.2023.315833
Nabil Mohie Abdel-Hamid; Mona Mohammed Abdel Hamid; Ahmed Abd El-Naser Mohamed; Ahmed Hassan Abd El-Salam Mohamed. "New predictive tools for liver fibrosis among non-apparently contaminated heavy metal workers". EKB Journal Management System, 5, 3, 2023, 195-207. doi: 10.21608/jmals.2023.315833
Abdel-Hamid, N., Abdel Hamid, M., Mohamed, A., Mohamed, A. (2023). 'New predictive tools for liver fibrosis among non-apparently contaminated heavy metal workers', EKB Journal Management System, 5(3), pp. 195-207. doi: 10.21608/jmals.2023.315833
Abdel-Hamid, N., Abdel Hamid, M., Mohamed, A., Mohamed, A. New predictive tools for liver fibrosis among non-apparently contaminated heavy metal workers. EKB Journal Management System, 2023; 5(3): 195-207. doi: 10.21608/jmals.2023.315833

New predictive tools for liver fibrosis among non-apparently contaminated heavy metal workers

Journal of Medical and Life Science
Volume 5, Issue 3, September 2023, Page 195-207  XML PDF (839.42 K)
Document Type: Original Article
DOI: 10.21608/jmals.2023.315833
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Authors
Nabil Mohie Abdel-Hamid1; Mona Mohammed Abdel Hamid2; Ahmed Abd El-Naser Mohamed email 3; Ahmed Hassan Abd El-Salam Mohamed4
1Department of Biochemistry, Faculty of Pharmacy, Kafrelsheikh University, Egypt,
2Department of Biochemistry, Faculty of Pharmacy (for Girls), Al-Azhar University, Egypt
3Department of Biochemistry, Faculty of Pharmacy, New Mansoura University, Egypt
4Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine (for Boys), Al-Azhar University, Egypt
Abstract
Background and aim: Accumulation of heavy metals, such as iron, copper, and lead can be hepatotoxic. This study aimed to investigate the effect of exposure to iron, copper, and lead on the liver, along with an experimental study. Methods: Thirty-six male workers from 3 factories in Egypt (12/each), lead, copper, and iron groups against a control group. Thirty-two rats were classified into 4 groups (8/each), control, iron (given oral ferrous gluconate, 10 mg/kg body weight), copper (given oral copper sulfate, 10 mg/kg body weight), and lead (given intraperitoneal lead acetate,8 mg/kg body weight) daily for 30 days. Results: Human iron, copper, and lead serum levels were non-significantly higher than control. Serum total glycosaminoglycans (TGAGs) and fibronectin (FN) were significantly raised in all workers with significant increases in alkaline phosphatase in iron and copper workers, and aspartate aminotransferase in ironworkers. Experimentally, liver hydroxy proline was significantly elevated, with disturbed tissue oxidative stress, serum liver indices with depressed hepatic tissue TGAG, and fibrosis among metal-loaded rats. Conclusion: The studied workers seem protected against metal intoxication, but non-significant serum increments could predict future hepatic fibrosis, manifested as correlative elevations in serum TGAGs and FN. Disrupted experimental fibro-genic parameters could explain our theory.
Keywords
Heavy metals; Fibrosis; Oxidative stress; Hepatotoxicity
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