Tumor Budding, Poorly Differentiated Clusters and Desmoplastic Reaction: New Evolving Prognostic Factors in Colorectal Cancer | ||||
| SECI Oncology Journal | ||||
| Volume 11, Issue 3, July 2023, Page 244-259 | ||||
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| Abstract | ||||
| Background: This study aimed to evaluate the application of the new assessment methods of tumor budding, poorly differentiated clusters and desmoplastic stromal reaction at the invasive front of colorectal carcinoma, assess and compare their prognostic impact and detect the association between (TB, PDCs and DR) and other conventional pathological parameters including TNM stage, perineural invasion and lymphovascular invasion. Methods: One hundred thirty-five cases of different stages of CRC with radical resection were included. Two pathologists independently examined Hematoxylin and Eosin-stained paraffin-embedded sections stained with Hematoxylin and Eosin according to the most recent assessment procedures for TB, PDC, and DR. Result: TB scores were strongly correlated with PNI (p = 0.012), pathologic N stage classification (p = 0.017), PDC (p <0.001), and DR (p <0.001), suggesting that it may be a good predictor of lymph node metastasis. The correlation between PDC grades and LVI (p=0.018), PNI (p=0.002), and DR (p<0.001) was statistically significant. There was a strong correlation between DR types and tumour size (p=0.007), LVI (p=0.011), and PNI (p<0.001). The OS was considerably impacted by TB, PDC, and DR, but only TB stratified survival rates independently of the conventional TNM stage and WHO tumour grade. Conclusion: Independent of the AJCC tumour staging criteria and other traditional histopathologic prognostic factors, the prognostic significance of TB evaluation according to the ITBCC recommendations was robust. | ||||
| Keywords | ||||
| tumor budding; poorly differentiated clusters; desmoplastic stromal reaction; colorectal cancer; prognosis | ||||
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