A study on the effect of cisplatin administration on the developing cerebellum in the albino rat and possible protective role of alpha lipoic acid | ||||
| The Egyptian Journal of Anatomy | ||||
| Volume 43, Issue 1, January 2020, Page 44-69 PDF (13.29 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/EJANA.2019.15681.1037 | ||||
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| Authors | ||||
Mohamed N. M. Saleh; Faten Y. Mahmoud; Ashraf H. Abd-Al Hakim; sally sayed Anwer 
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| Department of Human Anatomy and Embryology, Faculty of Medicine, Assiut University, Assiut, Egypt. | ||||
| Abstract | ||||
| The Cerebellum is highly organized structure. The aim of the present work is to study development of the cerebellum and effect of cisplatin on its development. Also, the possible protective role of alpha lipoic acid has been investigated. A total number of 40 pregnant females Albino rats were used. They divided into 4 groups: control group, cisplatin received group, alpha lipoic acid received group and both alpha lipoic acid and cisplatin received group. The rats received the treatment throughout the period of pregnancy and during the period of lactation. The offspring of rats at newly born, 10 days and 20 days old rats were sacrified. The present study showed that cisplatin causes degeneration of the neurons in the purkinje layer and granular layer in the cerebellar cortex and in deep cerebellar nuclei. Also, delayed development of the cerebellum could be observed. Morphometric results revealed statistically significant decrease in the number of pyrkinje and granule cells in cisplatin received group as compared with control group. Most of degenerative changes are improved by alpha lipoic acid. | ||||
| Keywords | ||||
| Alpha lipoic acid; cerebellum; cisplatin; immunohistochemistry; postnatal development; ultrastructural study | ||||
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