Helicobacter pylori antibiotic resistance patterns among Egyptian children and predictors of resistance

Abdallah, Nermeen M.A; Morsy, Reem Mohamed Ezzat; Awad, Yosra Mohamed Mohsen; Fathy, Marwa Saad; El Deeb, Marwa Talaat

doi:10.21608/mid.2023.230546.1596

	Helicobacter pylori antibiotic resistance patterns among Egyptian children and predictors of resistance
Microbes and Infectious Diseases
Article 26, Volume 4, Issue 4, November 2023, Page 1287-1295 PDF (635.4 K)
Document Type: Original Article
DOI: 10.21608/mid.2023.230546.1596
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Authors
Nermeen M.A Abdallah ¹; Reem Mohamed Ezzat Morsy²; Yosra Mohamed Mohsen Awad²; Marwa Saad Fathy¹; Marwa Talaat El Deeb²
¹Medical Microbiology and Immunology department, Faculty of Medicine, Ain Shams University, Cairo, Egypt
²Pediatrics department Faculty of Medicine - Ain Shams University- Cairo -Egypt
Abstract
Background: Helicobacter pylori (H. pylori) is a spiral-shaped Gram-negative bacteria that typically colonizes the stomach in early childhood. It is common worldwide, with higher rates in developing countries. Treatment eradication using first-line treatment regimens is declining, highlighting the importance of regional antibiotic resistance data to guide H. pylori treatment regimens. This study aimed at evaluation of antibiotic resistance patterns in H. pylori strains affecting pediatric patients and the predictors of this resistance. Patients and methods: This study included thirty pediatric patients who underwent endoscopic evaluation of their upper gastrointestinal symptoms at Ain Shams University pediatric hospital's gastroenterology unit. Five gastric biopsies were taken (from the corpus and antrum) for histopathology, rapid urease test and culture and sensitivity Results: According to culture and sensitivity results, resistance to metronidazole was the highest (86.7%), followed by clarithromycin (50%). Levofloxacin and tetracycline had the lowest resistance (6.7% and 13.3%, respectively). Excess fat consumption was associated with resistance to clarithromycin and amoxicillin. While duodenal nodularity and duodenal ulcer were associated with resistance to levofloxacin and tetracycline respectively. Conclusion: current H. pylori eradication regimen in Egypt, should be revised according to the local antibiotic susceptibility data. Further studies are needed to assess predictors for resistance to antibiotics.
Keywords
H pylori; antibiotic resistance; culture; predictors
Supplementary Files supplementary File.pdf 26-supplementary File.pdf

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