Protection of mice by oral vaccination with Brucella Melitensis vaccine (REV.1) in combination with flagellar protein against a virulent Brucella melitensis 16M strain
Farahat, L., El-Ayouby, S., Abdelwahab, M., Mustafa, A., Ebied, M. (2015). Protection of mice by oral vaccination with Brucella Melitensis vaccine (REV.1) in combination with flagellar protein against a virulent Brucella melitensis 16M strain. EKB Journal Management System, 29(2), 193-199. doi: 10.21608/bvmj.2015.31705
Lubna F. Farahat; Saleh M.S. El-Ayouby; Mohamed G. Abdelwahab; Abdel-Moneim Mustafa; Mohamed H. Ebied. "Protection of mice by oral vaccination with Brucella Melitensis vaccine (REV.1) in combination with flagellar protein against a virulent Brucella melitensis 16M strain". EKB Journal Management System, 29, 2, 2015, 193-199. doi: 10.21608/bvmj.2015.31705
Farahat, L., El-Ayouby, S., Abdelwahab, M., Mustafa, A., Ebied, M. (2015). 'Protection of mice by oral vaccination with Brucella Melitensis vaccine (REV.1) in combination with flagellar protein against a virulent Brucella melitensis 16M strain', EKB Journal Management System, 29(2), pp. 193-199. doi: 10.21608/bvmj.2015.31705
Farahat, L., El-Ayouby, S., Abdelwahab, M., Mustafa, A., Ebied, M. Protection of mice by oral vaccination with Brucella Melitensis vaccine (REV.1) in combination with flagellar protein against a virulent Brucella melitensis 16M strain. EKB Journal Management System, 2015; 29(2): 193-199. doi: 10.21608/bvmj.2015.31705

Protection of mice by oral vaccination with Brucella Melitensis vaccine (REV.1) in combination with flagellar protein against a virulent Brucella melitensis 16M strain

Benha Veterinary Medical Journal
Article 23, Volume 29, Issue 2, December 2015, Page 193-199  XML PDF (367.05 K)
Document Type: Original Article
DOI: 10.21608/bvmj.2015.31705
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Authors
Lubna F. Farahat1; Saleh M.S. El-Ayouby1; Mohamed G. Abdelwahab2; Abdel-Moneim Mustafa2; Mohamed H. Ebied2
1Antigens and Serums Dep., VSVRI. Abbasia, Cairo Egypt
2Animal Medicine Department, Faculty of veterinary Medicine, Benha University, Egypt
Abstract
We evaluated orally administered live attenuated B. melitensis Rev.1 vaccine in combination with
flagellin to protect mice against I/P challenge with Brucella melitensis 16M bacteria. Optimal protection
was enhanced by three booster immunization doses against challenge at 3 weeks post challenge.
Experiments were performed with mice to elucidate the roles of humoral and cell-mediated immune
responses in the acquisition of protective immunity to Brucella melitensis and to compare infection
immunity with immunity developed through vaccination with oral reduced dose of Rev.1 vaccine of B.
melitensis combined with flagellar protein (H7). Vaccination with reduced dose of Rev.1 vaccine orally
combined with flagellar protein is better than the vaccination with full dose of Rev.1 vaccine S/C in
mice. From the results its pointed out that the cell mediated immunity elicited by the use of oral reduced
dose of Rev.1 vaccine (3 Successive) dose combined with flagellar protein
Keywords
Brucella melitensis; flagellar protein; vaccine
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