Structure Investigation of Solid Ion Pairs of Three Azole Drugs-rose Bengal Using Different Spectroscopic Techniques and their Biological Activities | ||||
| Egyptian Journal of Chemistry | ||||
| Article 14, Volume 62, Issue 11, November 2019, Page 2143-2162 PDF (2.2 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejchem.2019.11907.1750 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Mohamed Zayed   1; Marwa A. Abdallah2
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| 1Department of chemistry, Faculty of Science, Cairo University (D.Sc. Anal.Chem.) | ||||
| 2National Organization for Drug Control and Research (NODCAR), Giza, Egypt | ||||
| Abstract | ||||
| In the present work is concerned with preparation, separation and structure elucidation of solid ion-pairs of three antifungal drugs Fluconazole (FLZ), Voriconazole (VRZ) and Butoconazole nitrate (BTZ) with Rose Bengal (Rbeng). The solid ion-pairs were prepared and investigated using FT-IR, mass spectral (MS) and thermal analyses (TA), in addition to elemental analysis (EA). The general formulae of the prepared ion-pairs were determined. Moreover, the formulae of prepared ion-pairs were proposed and structurally identified. The biological activities of the separated solid ion-pairs towards five types of bacteria and one type fungi in comparison with their drugs were studied, and they were found to be biologically active more than their parent drugs. | ||||
| Keywords | ||||
| Keywords: Imidazole drugs; Rose Bengal; Ion pairs; Infrared spectra; Thermal analysis; mass spectrometry; biological activities | ||||
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