Recent Updates in Treatment of Diabetic Neuropathy
Atef, M., El-Sayed, N., Mostafa, Y., Ahmed, A. (2019). Recent Updates in Treatment of Diabetic Neuropathy. EKB Journal Management System, 3(2), 15-27. doi: 10.21608/rpbs.2019.12385.1033
Mangreed Atef; Norhan Mohamed El-Sayed; Yasser Mohamed Mostafa; Amal Arafat Mokhtar Ahmed. "Recent Updates in Treatment of Diabetic Neuropathy". EKB Journal Management System, 3, 2, 2019, 15-27. doi: 10.21608/rpbs.2019.12385.1033
Atef, M., El-Sayed, N., Mostafa, Y., Ahmed, A. (2019). 'Recent Updates in Treatment of Diabetic Neuropathy', EKB Journal Management System, 3(2), pp. 15-27. doi: 10.21608/rpbs.2019.12385.1033
Atef, M., El-Sayed, N., Mostafa, Y., Ahmed, A. Recent Updates in Treatment of Diabetic Neuropathy. EKB Journal Management System, 2019; 3(2): 15-27. doi: 10.21608/rpbs.2019.12385.1033

Recent Updates in Treatment of Diabetic Neuropathy

Records of Pharmaceutical and Biomedical Sciences
Article 1, Volume 3, Issue 2, September 2019, Page 15-27  XML PDF (516.78 K)
Document Type: Mini-reviews
DOI: 10.21608/rpbs.2019.12385.1033
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Authors
Mangreed Atef email 1; Norhan Mohamed El-Sayedorcid 2; Yasser Mohamed Mostafa2; Amal Arafat Mokhtar Ahmed3
1Pharmacology & Toxicology, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt
2Department of Pharmacology & Toxicology, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt
3Department of Cytology & Histology, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, Egypt
Abstract
Diabetic neuropathy (DN) is a common complication of diabetes mellitus and is associated with structural changes in the nerves. Nerve damage happen as a result of many factors including metabolic disorders, oxidative and nitrosative stress, changes in the blood vessels that supply the peripheral nerves and changes in ion channel expression in peripheral fibres. However, the molecular basis for DN is poorly understood. Adenosine monophosphate activated protein kinase (AMPK) has been shown to regulate the activity of some kinases including protein kinase B (AKT), mitogen-activated protein kinases (MAPK) and mammalian target of rapamycin complex 1 (mTORC1) that represent important signalling pathways modulating the function of peripheral nociceptive neurons. Donepezil can activate AMPK and exerts neuroprotective effects. Diabetic mice showed reduced expression of p-AMPK in sciatic nerves with consequent activation of AKT/MAPK/4EBP1. In addition, a significant upregulation of the N-Methyl-D-aspartate (NMDA) receptors in spinal cord of diabetic mice was observed. Therefore, Donepezil could be a potential pharmacological agent for management of DN.
Keywords
Donepezil; Diabetic neuropathy; NMDA receptors; AMPK; MTORC1
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