Macrolactones and Macrolides from Plant Endophytic Fungi, Chemical Scaffolds, Biological Activities and Spectroscopy: A Comprehensive Review | ||||
| Bulletin of Pharmaceutical Sciences Assiut University | ||||
| Articles in Press, Accepted Manuscript, Available Online from 16 September 2023 | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bfsa.2023.224497.1834 | ||||
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| Authors | ||||
ehab Saad Elkhayat   1; Mohamed E Abouelela2; Reda Ahmed Abdelhamid2; Mohammad S Alorainy3; Khaled A Shaaban4
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| 1Faculty of Pharmacy | ||||
| 2Faculty of Pharmacy Al-Azhar university, Assuit breanch Assuit | ||||
| 3bDepartment of Pharmacology, College of Medicine, Qassim University, Saudi Arabia | ||||
| 4Center for Pharmaceutical Research and Innovation, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536, United States | ||||
| Abstract | ||||
| Background The pandemic of COVID-19 has stressed the exaggerated demand for innovative treatments, prompting the search for new sources. Plant endophytic fungi produce a diverse array of biologically active compounds, including macrolides and macrolactones with varying activities. Aim of the Study In this review we give an updated overview of natural macrolides and macrololactones from plant endophytes addressing original studies published up to June 2023. Results Over the preceding ten years, 91 macrolides with 80 novel compounds with cytotoxic, antibacterial, antifungal, and α-glucosidase inhibitory activities. Unfortunately, the number of novel chemicals identified from marine or bacterial endophytes in the same period is substantially lower. Accordingly, further study on plant endophytes, which are critical for drug research and the development of novel medicines, including antitumors, antivirals, antibacterials, and antimalarials, should be conducted. A report of the 13C NMR data of several endophytic macrolides are reported as a supplementary according to ring sizes and based on a united numbering built on literature search. | ||||
| Keywords | ||||
| Macrolides; plant endophytes; biosynthesis; biological activity; 13C-NMR | ||||
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Statistics Article View: 105 |
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