Relation between 25-hydroxy Vitamin D Levels and Neutrophil-to-Lymphocyte Ratio in Chronic Renal Disease Patients Under Hemodialysis
Abo-Elela, E., Ismail, M., salem, I., Sediq, A. (2023). Relation between 25-hydroxy Vitamin D Levels and Neutrophil-to-Lymphocyte Ratio in Chronic Renal Disease Patients Under Hemodialysis. EKB Journal Management System, (), -. doi: 10.21608/zumj.2023.231856.2861
Eman Ahmed Elsayed Abo-Elela; Mabrouk Ibrahim Ismail; ibrahim mohamed salem; Amany Mohyeldin Sediq. "Relation between 25-hydroxy Vitamin D Levels and Neutrophil-to-Lymphocyte Ratio in Chronic Renal Disease Patients Under Hemodialysis". EKB Journal Management System, , , 2023, -. doi: 10.21608/zumj.2023.231856.2861
Abo-Elela, E., Ismail, M., salem, I., Sediq, A. (2023). 'Relation between 25-hydroxy Vitamin D Levels and Neutrophil-to-Lymphocyte Ratio in Chronic Renal Disease Patients Under Hemodialysis', EKB Journal Management System, (), pp. -. doi: 10.21608/zumj.2023.231856.2861
Abo-Elela, E., Ismail, M., salem, I., Sediq, A. Relation between 25-hydroxy Vitamin D Levels and Neutrophil-to-Lymphocyte Ratio in Chronic Renal Disease Patients Under Hemodialysis. EKB Journal Management System, 2023; (): -. doi: 10.21608/zumj.2023.231856.2861

Relation between 25-hydroxy Vitamin D Levels and Neutrophil-to-Lymphocyte Ratio in Chronic Renal Disease Patients Under Hemodialysis

Zagazig University Medical Journal
Articles in Press, Accepted Manuscript, Available Online from 16 September 2023  XML
Document Type: Original Article
DOI: 10.21608/zumj.2023.231856.2861
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Authors
Eman Ahmed Elsayed Abo-Elela email 1; Mabrouk Ibrahim Ismail2; ibrahim mohamed salem3; Amany Mohyeldin Sediqorcid 4
1Resident at Hehia central Hospital-Nephrology unit
2internal medicine,faculty of medicine,zagazig university,zagazig,egypt
3Internal Medicine Department, Faculty of Medicine, Zagazig University, Sharkia Egypt
4clinical and chemical pathology, Faculty of Medicine, Zagazig University, Zagazig, Egypt
Abstract
Background: The progression of chronic kidney disease (CKD) toward the need for hemodialysis can be predicted by the neutrophil-to-lymphocyte ratio (NLR), NLR in hemodialysis patients may be predicted by their serum 25-hydroxy vitamin D levels. This study aimed to diagnose inflammation as early as possible among hemodialysis patients.

Subjects and methods: This cross-sectional study was done on 80 selected CKD patients from the nephrology units at Hehia Central Hospital and internal medicine department at Zagazig University Hospital. Subgroup analyses comparing the mean 25-hydroxy vitamin D (VD) levels and NLR between men and women, patients with and without the hypertensive disease (HTN), and patients with and without diabetes mellitus (DM).

Results: Mean level of Vitamin D was significantly higher in males than females with p value=0.001, however, a significantly higher NLR was found in females than in males with p value=0.001, Vit D level was significantly correlated with inflammatory markers (neutrophils, lymphocytes, as well as NLR with p value=0.001 for each), we found clinical and statistically significant prediction of NLR by Vit D with p value=0.001.

Conclusion: We showed a significant inverse correlation between serum vitamin D levels and the NLR values, which are inexpensive and broadly available inflammation markers. Our regression analyses indicate a significant relationship between these inflammatory markers and vit D levels level.
Keywords
25-hydroxy Vitamin D; Neutrophil-to-Lymphocyte Ratio; Chronic Renal Disease Hemodialysis
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