Oxytocin versus carbetocin for prevention of postpartum hemorrhage in high risk cases: Randomized controlled trial
Elgohary, A., Zayed, A., Refaie, E., Shams-Eldin, N. (2023). Oxytocin versus carbetocin for prevention of postpartum hemorrhage in high risk cases: Randomized controlled trial. EKB Journal Management System, 27(4), 46-54. doi: 10.21608/egyfs.2023.317677
Ayatallah Elsaeed Hammouda Elgohary; Abdelhady Abdelhady Mohamed Zayed; Ehsan Mohamed Raghib Refaie; Nermeen Shams-Eldin. "Oxytocin versus carbetocin for prevention of postpartum hemorrhage in high risk cases: Randomized controlled trial". EKB Journal Management System, 27, 4, 2023, 46-54. doi: 10.21608/egyfs.2023.317677
Elgohary, A., Zayed, A., Refaie, E., Shams-Eldin, N. (2023). 'Oxytocin versus carbetocin for prevention of postpartum hemorrhage in high risk cases: Randomized controlled trial', EKB Journal Management System, 27(4), pp. 46-54. doi: 10.21608/egyfs.2023.317677
Elgohary, A., Zayed, A., Refaie, E., Shams-Eldin, N. Oxytocin versus carbetocin for prevention of postpartum hemorrhage in high risk cases: Randomized controlled trial. EKB Journal Management System, 2023; 27(4): 46-54. doi: 10.21608/egyfs.2023.317677

Oxytocin versus carbetocin for prevention of postpartum hemorrhage in high risk cases: Randomized controlled trial

The Egyptian Journal of Fertility of Sterility
Article 6, Volume 27, Issue 4 - Serial Number 11106352, July 2023, Page 46-54  XML PDF (2.38 MB)
Document Type: Original Article
DOI: 10.21608/egyfs.2023.317677
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Authors
Ayatallah Elsaeed Hammouda Elgohary* 1; Abdelhady Abdelhady Mohamed Zayed1; Ehsan Mohamed Raghib Refaie1; Nermeen Shams-Eldin2
1Obstetrics and gynecology, Faculty of medicine, Mansoura University, Egypt.
2Obstetrics and gynecology, Faculty of medicine, Mansoura University, Egypt
Abstract
Abstract 
Objective: To assess the effectiveness of oxytocin compared to carbetocin in patients with high risk factors for atonic postpartum hemorrhage who are undergoing elective caesarean section for prophylaxis against postpartum hemorrhage. 
Subjects and methods: This randomized controlled study was conducted on 100 pregnant women undergoing elective caesarean section and had high risk factors for atonic PPH. Group (1): were given oxytocin 10 (IU) and Group (2):  were given 1 ml of carbetocin. The study was approved by the Ethics Committee, and all patients gave their informed consent before inclusion in the study.  
Results: We found that there was a statistically significant differences between the two groups as regard the need for additional uterotonic agents, need for uterine massage, estimated mean operative blood loss, hemoglobin 24 hours after operation and incidence of major obstetric hemorrhage (P-value < 0.05).  
Conclusion: The current study has demonstrated that carbetocin can be alternative to traditional oxytocin in the prevention of postpartum hemorrhage in high-risk women undergoing elective caesarean section.   
Keywords
Key words: Oxytocin; carbetocin; high risk; postpartum hemorrhage; elective caesarean section; randomized controlled study
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