Evaluation of Serum Zinc Level in Children with Autism Spectrum Disorders | ||||
| Zagazig University Medical Journal | ||||
| Article 49, Volume 31, Issue 1.1, January 2025, Page 439-445 PDF (856.57 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/zumj.2023.235840.2885 | ||||
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| Authors | ||||
Safaa Hamdy Ahmad1; Huda E. M. Said 2; Aladdin Ramadan Taieb El-Maktouf  3; Mahmoud Mohammed El Sayed Elgohary1
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| 1Pediatrics Department, Faculty of Medicine, Zagazig University, Egypt | ||||
| 2Clinical Pathology Department, Faculty of Medicine, Zagazig University, Egypt | ||||
| 3Pediatrics Department, Faculty of Medicine, Tripoli University – Libya | ||||
| Abstract | ||||
| Background: A deficiency or excess of key minerals and trace elements has been linked to a number of health issues, including the etiology of autism spectrum disorder (ASD). ASD children appear to be at risk for zinc insufficiency. Therefore, the present study aimed at the early diagnosis of children with autism spectrum disorders and assessed serum zinc levels in children with ASDs. Patients and methods: This case control study was conducted on outpatient clinics of pediatrics and psychiatry department, Faculty of Medicine, Zagazig University. Parents of children aged 3–11 years with ASD were invited to participate in the study. 23 children with autism who were diagnosed using the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR) and the Childhood Autism Rating Scales (CARS) and who did not have another medical condition. The control group included 23 seemingly healthy children who were age and gender matched to the patients. Pediatricians clinically assessed all controls to rule out the possibility of subclinical autistic characteristics. Results: Serum zinc was significantly decreased in ASD group than control group (P value <0.001). Serum zinc can significantly diagnose ASD in children (AUC= 0.946, P value <0.001) at cut off ≤ 48, 95.65% sensitivity, 91.30% specificity, 91.7% PPV and 95.5% NPV. Conclusion: There was an association between serum levels of zinc in children and the zinc could be considered a biomarker of ASD. | ||||
| Keywords | ||||
| Autistic spectrum disorder; Zinc; Children | ||||
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