Relationship between peripapillary retinal nerve fiber layer and visual field severity indices in primary open angle glaucoma
Abdelatif, I., Radwan, G., Gaber, M., Mahmoud, S. (2018). Relationship between peripapillary retinal nerve fiber layer and visual field severity indices in primary open angle glaucoma. EKB Journal Management System, 22(3), 157-162. doi: 10.21608/smj.2018.31807
Ismael Abdelatif; Gamal Abdellatif Radwan; Mohammed Ezz Eldawla Gaber; Sara Mahmoud. "Relationship between peripapillary retinal nerve fiber layer and visual field severity indices in primary open angle glaucoma". EKB Journal Management System, 22, 3, 2018, 157-162. doi: 10.21608/smj.2018.31807
Abdelatif, I., Radwan, G., Gaber, M., Mahmoud, S. (2018). 'Relationship between peripapillary retinal nerve fiber layer and visual field severity indices in primary open angle glaucoma', EKB Journal Management System, 22(3), pp. 157-162. doi: 10.21608/smj.2018.31807
Abdelatif, I., Radwan, G., Gaber, M., Mahmoud, S. Relationship between peripapillary retinal nerve fiber layer and visual field severity indices in primary open angle glaucoma. EKB Journal Management System, 2018; 22(3): 157-162. doi: 10.21608/smj.2018.31807

Relationship between peripapillary retinal nerve fiber layer and visual field severity indices in primary open angle glaucoma

Sohag Medical Journal
Article 18, Volume 22, Issue 3, October 2018, Page 157-162  XML PDF (62.53 K)
Document Type: Original Article
DOI: 10.21608/smj.2018.31807
View on SCiNiTO View on SCiNiTO
Authors
Ismael Abdelatif1; Gamal Abdellatif Radwan2; Mohammed Ezz Eldawla Gaber3; Sara Mahmoud3
1Department of Ophthalmology, Faculty of Medicine, Sohag University.
2Department of Ophthalmology, Faculty of Medicine, Sohag University.
3Department of Ophthalmology, Faculty of Medicine, Sohag University
Abstract
Background: Optical Coherence Tomography (OCT) and visual field (VF) are devices for diagnosis and management of glaucoma. Using both techniques enable us to detect the functional and anatomical changes occur in glaucomatous eyes. Objectives: In this study, we aimed to determine the relationship between optical coherence tomography (OCT) parameters and visual field severity indices computed by standard automated perimetry (SAP) in patients with primary open angle glaucoma and to know the correlation between OCT disc parameter and ganglion cell layer (GCL).
Methods: The study included 94 subjects (160 eyes) divided into two groups. Group1 included 54 subjects with primary open angle glaucoma (cases) (92 eyes) Group 2 included 40 healthy non-glaucomatous subjects (controls) (68eyes).OCT disc &macula and VF using standarded automated perimetry were performed for all participants in both groups. Correlations between OCT parameters and VF parameters and between OCT disc parameters and GCL were detected. Area under curve (AUC) was used to detect most important factor to differentiate cases from control. Results: We found strong correlations between MD and each of  total , Inferior , Superior p RNFL respectively , PSD  is moderately correlated with total ,inferior and superior  p RNFL and vertical CDR  respectively ,Inferior p RNFL is strongly correlated to inferior GCLcomplex. Regarding the "area under curve (AUC)" : the most important factors to differentiate cases from control are in order: total GCC, followed by inferior GCC, then total p .RNFL.
Conclusion : macular scans may be a good alternative to p. RNFL thickness assessment for the detection of glaucoma, we should perform VF test with both macular and p.RNFL scanning in all subjects suspected or known to have glaucoma for better and earlier diagnosis as they improve the sensitivity of glaucoma detection.
Keywords
OCT; VF; Glaucoma; macular ganglion cell layer
Supplementary Files
References
1. Huang D, Swanson EA, Lin CP, et al.Optical coherence tomography. Science 1991;254: 1178–1181

2. Harrington D, Drake M. The visual fields: a textbook and atlas of clinical perimetry, 6th edn, St Louis, Mosby, 1990: 42-47

3.Chen Y., Chen  J and  Da-Wen L.," Comparison of the Humphrey Field Analyzer and Humphrey Matrix Perimeter for the Evaluation of Glaucoma Patients " Ophthalmologic 222(6), 2008: 407-411

4. Yaqub M.: Visual fields interpretation in glaucoma: a focus on Static Automated Perimetry. Com Eye Health. 2012;25 (79-80): 1-8. E-Pub 2013 Jun 4.

5. Kang E., Hong S., Kim C. et al.: Relationship between peripapillary retinal nerve fiber layer thickness measured by optical coherence tomography and visual field severity indices. Korean J Ophthalmol. 2015;29(4):263-269.

6. Jonas J, Fernandez M and Sturmer J.  Pattern of glaucomatous neuroretinal rim loss. Ophthalmology 1999 ; 100: 63-68.

7. Pederson J and Anderson D. The mode of progressive disc cupping in ocular hypertension and glaucoma. Arch Ophthalmol 2001: 490-495.

8. Rao H, Zangwill L, Weinreb R, et al. Comparison of different spectral domain optical coherence tomography scanning areas for glaucoma diagnosis. Ophthalmology 2010; 117: 1692-1699.

9. Wang X, Li S, Fu J, et al. Comparative study of retinal nerve fibre layer measurement by RTVue OCT and GDx VCC. Br JOphthalmol 2011; 95: 509-513.

10. Kim N, Lee E, Seong G, et al. Comparing the ganglion cell complex and retinal nerve fibre layer measurements by Fourier domain OCT to detect glaucoma in high myopia. Br J Ophthalmol. 2011; 95(8):1115–1121.

11. Sung K, Wollstein G, Kim N, et al. Macular assessment using optical coherence tomography for glaucoma diagnosis. Br JOphthalmol 2012; 96: 1452-1455.

12.Hood D., Raza A., de Moraes C. et al.: Glaucomatous damage of the macula. ProgRetin Eye Res. 2013;32: 1-21.

13. Lisboa R., Paranhos A., Weinreb R., et al.: Comparison of different spectral domain OCT scanning protocols for diagnosing preperimetric gla ucoma. Invest Ophthalmol Vis Sci. 2013;54: 3417-3425

14. GadiWollstein M, Joel S., Lori L., etal., American Journal of ophthalmology ,volume 138 ,Issue 2 ,August 2004,218-225.

 

 

 

 

Statistics
Article View: 209
PDF Download: 263