Biochemical effect of Moringa peregrina Seeds on experimentally leukcytopenia in Rats | ||||
| Benha Veterinary Medical Journal | ||||
| Article 20, Volume 29, Issue 1, September 2015, Page 151-163 PDF (390.92 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bvmj.2015.31813 | ||||
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| Authors | ||||
| Abdel-Maksoud H. A.1; Afaf D. Abd El Mageed1; Wafaa Abd El Zaher Taha1; Mohammed A. Hussein2 | ||||
| 1Biochemistry Department, Faculty of Veterinary Medicine, Benha University, Egypt | ||||
| 2Biochemistry Department, Faculty of Pharmacy, October 6th University, Egypt | ||||
| Abstract | ||||
| The present study was to evaluate anti-leukopenia and antioxidant effects of Moringa peregrina seeds oil at dose of 381 mg/kg in 400mg/kg.b.w Benzene and/or 20 mg/kg.b.w 5-Flourourasil induced leukopenia rats 2 weeks after induction of leukopenia in rats, Moringa peregrina seeds oil at dose of 381 mg/kg was administrated for 30 consecutive days. On the 31th day, the rats were sacrificed for the estimation of Hemoglobin (Hb%), Total Leucocyte Count (WBC) and Platelet Count (PLT) as well as biochemical parameters; Alanine Transaminase (ALT), Aspartate Transaminase (AST), Alkaline Phosphatase (ALP), Albumin(Alb) , Total Protein, Lactate Dehydrogenase (LDH), Creatine Kinase (C.K), Urea , Creatinine ,Reduced Glutathione (GSH), Superoxide Dismutase (SOD), Catalase (CAT), Total Cholesterol (T.Ch), Triglycerides (TG), P53 Gene Expression, Nitric Oxide (NO) , Thiobarbituric Acid Reactive Substances (TBARs) and Tumor Necroses Factor-α (TNF-α). The results of this study also showed that administration of Moringa peregrina seeds oil at dose of 381 mg/kg.b.w to leukopenia induced rats demonstrated a significant (P<0.01) increase in Hb%, WBCs and PLT as well as a significant (P<0.01) improvement in biochemical parameters and life span as compared to the benzene and /or 5-Flourourasil control rats. The histological examinations of this study revealed lung damage and degeneration in the lung of benzene and /or 5-Flourourasil treated rats. Also, lung of Moringa peregrina seeds oil at 381mg/kg rats showed significant improvement and protection against benzene and /or 5-Flourourasil harmful effect. On the other hand, the results clearly suggest that the oxidative stress of benzene higher than 5-Flourourasil | ||||
| Keywords | ||||
| Moringa seeds oil; 5-Flourourasil; Benzene; leukopenia and antioxidants | ||||
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