Vitamin D Status in Children with Type 1 Diabetes, Upper Egypt | ||||
| The Medical Journal of Cairo University | ||||
| Volume 91, Issue 06, June 2023 PDF (282.54 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/mjcu.2023.318242 | ||||
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| Author | ||||
| SAFYNAZ M. AMEEN, M.Sc.* and EMAN F. GAD, M.D.* OSAMA M. EL-ASHEER, M.D.*; DEIAAELDIN M. TAMER, M.D.*; AMAL A. MAHMOUD, M.D.**; | ||||
| The Departments of Pediatrics* and Clincal Pathology**, Faculty of Medicine, Assiut University | ||||
| Abstract | ||||
| Abstract Background: Type 1 diabetes Mellitus is a result of the autoimmune destruction of beta cells leading to insulin defi-ciency. Vitamin D deficiency may have a role in the develop-ment and pathogenesis of type-1 diabetes Mellitus by modu-lating immune mechanisms. Aim of Study: Our study is a cross-sectional study aimed to assess the level of 25-hydroxy vitamin D in children with type 1 diabetes Mellitus. Patients and Methods: Eighty patients attending the endocrinology clinic in the period from November 2016 to August 2017 were included, their ages ranged from 5 years to 15 years and all patients proved as having type 1 diabetes mellitus and were on insulin therapy. All patients were sub-jected to full history taking, and clinical examination in addition to the assessment of vitamin D status with measuring of serum 25-hydroxyvitamin D level in a venous blood sample. Results: The incidence of type 1 diabetes was greater in females (65%) than in males (35%). Ages between 10-15 years were more commonly affected than the younger age group (5-10) years. Higher rates were recorded in urban than rural areas. 40% of studied children with type 1 diabetes had vitamin D deficiency but 60% of them had a sufficient level of vitamin D. Vitamin D insufficiency with type 1 DM was more common in females (83.9%), in age group (10-15) years (74%), in urban population (67%) and in children with daily consumption of junk food (64.50%). Type 1 diabetic children with vitamin D insufficiency were more liable to frequent infections and hospital admission (90%). Conclusion: Our study concludes that vitamin D deficiency was significantly detected in type 1 diabetic children. In addition, vitamin D deficiency in these patients is associated with frequent hospital admission and complications. | ||||
| Keywords | ||||
| Type 1 Diabetes; Vitamin D; Children | ||||
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